Severe asthma: Comparison of different classifications of severity and control

Respiratory Medicine
Alexssandra Maia AlvesA A Cruz

Abstract

Criteria of asthma severity and control lack standardization. to compare classifications of asthma severity and control, applied to patients from a severe asthma clinic. Cross-sectional study of 473 patients followed up for ≥6 months, reclassified using three criteria: 1) the World Health Organization (WHO) 2010, 2) the American Thoracic Society (ATS) 2000, and 3) the European Respiratory Society (ERS)/ATS 2014. In order to evaluate disease control, the 2012 and 2014 Global Initiative for Asthma (GINA) classifications were compared. According to the definition of WHO 2010, 429 had Difficult-to-treat severe asthma and only 12 presented Treatment-resistant severe asthma. 114 patients had Refractory asthma by ATS 2000 and 88 had Severe asthma by ERS/ATS 2014. Considering the definitions of WHO 2010, only 9 out of 12 with Treatment-resistant and 64 out of 429 with Difficult-to-treat severe asthma met the criteria of ATS 2000 and ERS/ATS 2014. As for GINA classification of control, 208 (44%) of the 473 subjects were classified as having asthma controlled by the 2014 criteria, whereas only 45 (10%) patients had controlled asthma by the GINA 2012 criteria. The Kappa statistic indicates the highest agreement of the severity classificat...Continue Reading

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Apr 10, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Luane Marques MelloAlvaro A Cruz
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vitor PonciJoão Henrique G Lago
Jul 10, 2021·BMC Pulmonary Medicine·Sanna Toppila-SalmiValérie Siroux

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