Abstract
Very few studies have explored the distinguishing features of severe asthma in childhood in Europe, and only one study was conducted in Southern Europe. The aim of this study was to provide a detailed characterization of children with severe asthma treated in specialized pediatric asthma centers across Italy. We conducted a web-based data collection of family, environmental, clinical and laboratory characteristics of 41 patients aged 6-17 years with severe asthma, defined according to the recent guidelines of the European Respiratory Society and the American Thoracic Society, and 78 age-matched peers with non-severe persistent asthma. The patients have been enrolled from 16 hospital-based pediatric pulmonology and allergy centers in Northern, Central, and Southern Italy. Logistic regression analysis assessed the relationship between patients' characteristics and severe asthma or non-severe persistent asthma. Features independently and significantly associated with severe asthma included lifetime sensitization to food allergens [Odds ratio (OR), 4.73; 95 % Confidence Interval (CI), 1.21-18.53; p = 0.03], lifetime hospitalization for asthma (OR, 3.71; 95 % CI, 1.11-12.33; p = 0.03), emergency-department visits for asthma during t...Continue Reading
References
Feb 1, 1994·The American Journal of Clinical Nutrition·J H Himes, W H Dietz
Feb 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·E F JuniperM Townsend
Aug 1, 1997·The European Respiratory Journal
Sep 12, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·S M TariqS H Arshad
Mar 4, 2003·Pediatrics·Anne Kotaniemi-SyrjänenMatti Korppi
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
May 4, 2005·The Journal of Allergy and Clinical Immunology·Julie WangHugh A Sampson
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Apr 3, 2007·The Journal of Allergy and Clinical Immunology·Bradley E ChippsUNKNOWN TENOR Study Group
May 1, 2007·Pediatric Pulmonology·Alyson B SimpsonEjaz Yousef
May 9, 2009·BMC Pediatrics·Giampaolo RicciMassimo Masi
Dec 31, 2009·Acta Paediatrica·A M LangK C Lødrup Carlsen
Jul 3, 2010·The European Respiratory Journal·G HedlinUNKNOWN Problematic Severe Asthma in Childhood Initiative group
Aug 20, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Astri LangKarin C Lødrup Carlsen
Sep 10, 2010·Health and Quality of Life Outcomes·Bonnie B DeanDavid Tinkelman
Oct 1, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jon R KonradsenUNKNOWN Swedish Network of Pediatric Allergists, Severe Asthma Network
Oct 6, 2010·The Journal of Allergy and Clinical Immunology·Andrew H LiuDarryl C Zeldin
Oct 30, 2010·The European Respiratory Journal·K C Lødrup CarlsenUNKNOWN PSACI (Problematic Severe Asthma in Childhood Initiative) group
Jan 5, 2011·The Journal of Allergy and Clinical Immunology·Anne M FitzpatrickUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
May 21, 2011·Acta Paediatrica·B NordlundG Hedlin
Jan 24, 2012·The European Respiratory Journal·Jocelyne JustIsabella Annesi-Maesano
Feb 14, 2012·General Hospital Psychiatry·Antje-Kathrin AllgaierGerd Schulte-Körne
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative
Sep 11, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Yanxia LuRoger Chun-Man Ho
Mar 23, 2013·The European Respiratory Journal·Antoine DeschildreJocelyne Just
Dec 18, 2013·The European Respiratory Journal·Kian Fan ChungW Gerald Teague
Jan 15, 2014·Allergy·A CustovicN G Papadopoulos
Sep 2, 2014·The Journal of Pediatrics·Elizabeth D SchifanoMichelle M Cloutier
Oct 29, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Mark L Levy
Citations
Apr 20, 2016·Frontiers in Pediatrics·Carlo CaffarelliCarlotta Povesi Dascola
Jul 15, 2016·Italian Journal of Pediatrics·Panayiotis K YiallourosPierre Zalloua
Oct 20, 2018·The European Respiratory Journal·Franca RusconiUNKNOWN European Lung Foundation severe asthma patient advisory group
Apr 6, 2019·Expert Review of Respiratory Medicine·Amelia LicariGiorgio Ciprandi
Apr 4, 2020·Expert Opinion on Biological Therapy·Giovanni Battista PajnoGian Luigi Marseglia
Feb 14, 2020·Expert Opinion on Biological Therapy·Amelia LicariGiorgio Ciprandi
Feb 29, 2020·Minerva pediatrica·Riccardo CastagnoliAmelia Licari
Jul 19, 2018·Italian Journal of Pediatrics·Carlo CaffarelliGiovanni Corsello
Jan 16, 2019·Italian Journal of Pediatrics·Giuseppe CrisafulliGiovanni Battista Pajno
Mar 12, 2020·Paediatric Drugs·Amelia LicariGian Luigi Marseglia
Jul 22, 2020·International Journal of Immunopathology and Pharmacology·Jakub Novosad, Irena Krčmová
Jun 5, 2020·Breathe·Amelia LicariGian Luigi Marseglia
Jul 5, 2018·Frontiers in Pediatrics·Amelia LicariGian L Marseglia
Feb 6, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Laura TeneroGiorgio Piacentini
Feb 6, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Amelia LicariGian Luigi Marseglia
Apr 26, 2020·Scientific Reports·Laura MontalbanoUNKNOWN Italian Pediatric Severe Asthma Network (IPSAN) Program of Italian Paediatric Respiratory Society (IPRS)
Sep 17, 2017·Italian Journal of Pediatrics·Carlo CaffarelliSergio Bernasconi
Feb 23, 2018·BMC Pediatrics·Virginia MirraFrancesca Santamaria
Jul 22, 2019·Paediatric Drugs·Amelia LicariGian Luigi Marseglia
Feb 1, 2019·Frontiers in Pediatrics·Marco MaglioneFrancesca Santamaria
Oct 16, 2020·Pediatric Pulmonology·Delaney GriffithsJonathan M Gaffin
Nov 26, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Riccardo CastagnoliGian Luigi Marseglia
Jan 29, 2021·Expert Opinion on Biological Therapy·Francesco MenzellaAndrea Matucci
Jan 31, 2021·Journal of Affective Disorders·Danilo CarrozzinoFiammetta Cosci
Dec 6, 2020·BMC Public Health·Laura CaccianiMarina Davoli
May 14, 2021·Biologics : Targets & Therapy·Martina VottoGian Luigi Marseglia
Aug 14, 2021·Journal of Pharmacy Practice·Lu ChengYongtai Wang