Severe Atopic Dermatitis in Children

Current Allergy and Asthma Reports
Evie Huang, Peck Y Ong

Abstract

Severe atopic dermatitis (AD) in childhood leads to significant morbidity including psychosocial problems and infectious complications. There are only a few approved treatment options for these patients. These include topical corticosteroids and tacrolimus ointment, which are associated with potential side effects. In order to find better and safer treatments, further understanding of AD mechanisms is needed. Primary skin barrier defects play an important role in the pathogenesis of AD. In addition, the suppression of skin barrier functions by Th2 inflammation also plays an important role in the persistence and recurrence of AD. Cytokines in the Th2 pathway, which includes IL-4, IL-13, TSLP, IL-25, IL-31, and IL-33, are potential therapeutic targets in AD. Other potential targets of AD are Janus kinase, phospholipase A2, aryl hydrocarbon receptor, and skin microbiota. A better understanding of the pathogenesis of AD will provide future direction for treatment.

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Citations

Oct 1, 2019·Pediatric Dermatology·Stephanie C Blake, Dedee F Murrell
Jul 29, 2020·Expert Review of Clinical Immunology·Sonja SennerAndreas Wollenberg
Mar 23, 2021·The World Allergy Organization Journal·William López-QuinteroManuela Olaya
Mar 11, 2021·Journal of the American Academy of Dermatology·Amy H HuangShawn G Kwatra
Aug 28, 2021·The Journal of Dermatological Treatment·Annalisa PatriziGiampiero Girolomoni

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