Severe autoimmune hemolytic anemia in a liver transplanted child

Pediatric Transplantation
Michela G SchäppiMichèle A Siegenthaler

Abstract

AIHA can complicate solid organ and bone marrow transplantation early after transplant. We describe the first case report of a 16-month-old boy with mixed type warm-acting IgM and warm IgG autoantibodies AIHA, occurring eight months after liver transplantation. This case describes the complexity of this very rare form of AIHA. It also illustrates the efficacy of rituximab in this indication, as well as the transfusion support with extremely rare blood, along with the importance of international collaboration to provide it. In this report, the etiologies of HA occurring in post-transplant pediatric patients are reviewed and the different treatment strategies are discussed.

References

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Citations

Apr 8, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Piotr CzubkowskiGirish Gupte
May 7, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Gonzalo BotijaGerardo Prieto
Jan 19, 2010·Pediatric Transplantation·Valérie A McLinKlara M Posfay-Barbe
Jun 9, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroyuki TakahashiSumio Kai
Jun 18, 2017·Clinical Transplantation·Theoni Kanellopoulou
Jun 10, 2018·Pediatric Transplantation·Nathalie RockValérie Anne McLin
Dec 6, 2021·Laboratory Medicine·Precious FortesDawn C Ward

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Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.