Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke

Frontiers in Neurology
Chang LiuMin Lou

Abstract

Previous studies demonstrated that cardioembolism (CE) was prone to develop hemorrhagic transformation (HT), whereas hyper-permeability of blood-brain barrier (BBB) might be one reason for the development of HT. We, thus, aimed to investigate whether the BBB permeability (BBBP) was higher in CE stroke than other stroke subtypes in acute ischemic stroke (AIS) patients. This study was a retrospective review of prospectively collected clinical and imaging database of AIS patients who underwent CT perfusion. Hypoperfusion was defined as Tmax >6 s. The average relative permeability-surface area product (rPS), reflecting the BBBP, was calculated within the hypoperfusion region (rPShypo). CE was diagnosed according to the international Trial of Org 10172 in Acute Stroke Treatment criteria. Receiver operating characteristics (ROC) curve analysis was used to determine predictive value of rPShypofor CE. Logistic regression was used to identify independent predictors for CE. A total of 187 patients were included in the final analysis [median age, 73 (61-80) years; 75 (40.1%) females; median baseline National Institutes of Health Stroke Scale score, 12 (7-16)]. Median rPShypowas 65.5 (35.8-110.1)%. Ninety-seven (51.9%) patients were diagno...Continue Reading

References

Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K S St Lawrence, T Y Lee
Dec 12, 2001·Stroke; a Journal of Cerebral Circulation·J MontanerJ Monasterio
Sep 25, 2004·Annals of Neurology·Lawrence L LatourSteven Warach
Oct 2, 2004·Stroke; a Journal of Cerebral Circulation·Xiaoying WangEng H Lo
Aug 16, 2006·Journal of Thrombosis and Haemostasis : JTH·J M OlivotUNKNOWN GENIC Investigators
Mar 18, 2008·Journal of the American College of Cardiology·Eleni DoufekiasJorge R Kizer
Jul 19, 2008·AJNR. American Journal of Neuroradiology·J W DankbaarM Wintermark
Sep 16, 2008·Neurobiology of Disease·Karin E Sandoval, Ken A Witt
Nov 26, 2008·Neurology·O Y BangUNKNOWN UCLA Collateral Investigators
Feb 27, 2009·Radiology·Richard I AvivTing-Yim Lee
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Christoph R W KuhlmannHeiko J Luhmann
Mar 3, 2009·Journal of Neuroradiology. Journal De Neuroradiologie·J W DankbaarM Wintermark
Oct 19, 2010·Journal of Neuroradiology. Journal De Neuroradiologie·J W DankbaarM Wintermark
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMark W Parsons
Aug 1, 2013·Cerebrovascular Diseases·P AmarencoM G Hennerici
Nov 12, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Bruce C V CampbellUNKNOWN EXTEND-IA investigators
May 31, 2014·Stroke; a Journal of Cerebral Circulation·Richard LeighUNKNOWN STIR and VISTA Imaging Investigators
Jun 5, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Be'eri Niego, Robert L Medcalf
Sep 12, 2015·Metabolic Brain Disease·Marcio Francisco LehmannEdna Maria Vissoci Reiche
Jul 28, 2016·Stroke; a Journal of Cerebral Circulation·Alexis N SimpkinsUNKNOWN National Institutes of Health Natural History of Stroke Investigators
Apr 23, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L C RebelloR G Nogueira

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Methods Mentioned

BETA
imaging technique

Software Mentioned

MIStar
SPSS

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