PMID: 11341107May 9, 2001Paper

Severe bone marrow failure associated with the use of alternating steroid with chlorambucil in lupus membranous nephropathy in Chinese

Lupus
A Y WangS F Lui

Abstract

Severe pancytopenia associated with the use of alternating steroid with chlorambucil regimen was described in six patients with nephrotic syndrome secondary to lupus membranous nephropathy (WHO class V). We believe this is the first report describing the life-threatening degree of marrow toxicity associated with this regimen of alternating steroid with chlorambucil in a Chinese population. Our data suggests that the susceptibility to marrow toxicity with the use of chlorambucil may only be applicable to Chinese patients with underlying systemic lupus erythematosus as a similar degree of toxicity has neither been reported in lupus patients of other ethnic groups nor in non-lupus patients of Chinese origin.

References

Nov 1, 1977·Medicine·J V DonadioK E Holley
Jan 1, 1991·Pathology·C S FengE K Li
Apr 12, 1984·The New England Journal of Medicine·C PonticelliT Volpini
Feb 1, 1996·Journal of the American Society of Nephrology : JASN·R P SloanR Z Borok
Apr 8, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G MoroniC Ponticelli

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Citations

Sep 5, 2002·Arthritis and Rheumatism·Sharon L KolasinskiDaniel A Albert
Mar 27, 2009·Nature Reviews. Nephrology·Chi Chiu Mok
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Howard A AustinJames E Balow
May 23, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Pijus SahaGervais Bérubé
Mar 4, 2010·Annals of Biomedical Engineering·F R BaxterA C E Dent

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