Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection

BMJ Case Reports
Lotte EbdrupTrine Hyrup Mogensen

Abstract

Systemic capillary leak syndrome (SCLS), also known as Clarkson syndrome, is a rare disease with potential fatal outcome. The clinical picture involves leakage of fluid and protein from the bloodstream into peripheral tissues, resulting in hypoalbuminaemia, elevated haematocrit, oedema and hypotension. The spectrum of the symptoms ranges from discrete swelling/oedema of extremities to fulminant cardiogenic shock. We present a case with a 52-year-old man diagnosed with SCLS after being resuscitated from cardiac arrest, which was complicated by compartment syndrome. The severe episode of capillary leak was potentially triggered by influenza virus infection. With the benefit of hindsight, he presented with symptoms of SCLS 2 years prior the major acute episode. Here we describe this case and review some aspects of the literature on SCLS, with particular focus on the pathogenesis, treatment/prophylaxis and long-term physical and psychological complications.

References

Aug 1, 1960·The American Journal of Medicine·B CLARKSONE H LUCKEY
Jun 17, 2008·Critical Care Medicine·Marc LambertPierre-Yves Hatron
Aug 26, 2009·The Journal of Allergy and Clinical Immunology·Amy M DowdenZuhair K Ballas
Apr 6, 2011·Annals of Internal Medicine·Marie GousseffUNKNOWN Capillary Leak Syndrome Registry
Sep 7, 2014·The American Journal of Medicine·Zhihui XieKirk M Druey
Nov 19, 2014·Journal of Clinical & Cellular Immunology·Zhihui XieKirk M Druey
Feb 26, 2015·Pediatrics·Peter HsuKirk M Druey
Jul 19, 2016·Expert Opinion on Drug Metabolism & Toxicology·Livia DézsiLászló Vécsei
Dec 26, 2016·The Journal of Allergy and Clinical Immunology·Kirk M Druey, Samir M Parikh
Jun 13, 2017·The American Journal of Medicine·Marc Pineton de ChambrunUNKNOWN EurêClark Study Group
Jun 18, 2017·Critical Care Medicine·Marc Pineton de ChambrunUNKNOWN EurêClark Study Group
Sep 25, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Tae Seong EoJae Il Shin

❮ Previous
Next ❯

Citations

May 1, 2021·International Journal of Molecular Sciences·Christian J Wiedermann
Jun 9, 2021·La Revue de médecine interne·A BichonJ Carvelli

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation
PCR
electrophoresis

Related Concepts

Related Feeds

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.

Related Papers

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Christos KaratziosPhilippe Ovetchkine
The Medical Journal of Australia
S R HagleyP C Blumbergs
American Journal of Respiratory and Critical Care Medicine
Zhihui XieKirk M Druey
© 2022 Meta ULC. All rights reserved