Severe central sleep apnoea associated with nalmefene: a case report

British Journal of Clinical Pharmacology
Charles KhouriRenaud Tamisier

Abstract

Nalmefene, an opioid antagonist, has recently been approved for the treatment of alcohol dependence. We describe here the first case of a 52-year-old woman who developed a severe central sleep apnoea (CSA) 5 months after initiation of nalmefene. Scoring of ventilation during sleep recording revealed an apnoea-hypopnoea index of 67/h with 98.7% of central events and an apnoea index of 65/h. Nalmefene was withdrawn and a new polysomnography was performed which concluded that CSA has disappeared. Pathophysiology is still unclear but could involve the κ-opioid receptors. Physicians should be aware that CSA might affect patients treated with nalmefene. Further investigations are required to determine the pathophysiology, frequency, and treatment of CSA associated with nalmefene and other therapy for alcohol disorders.

References

Feb 11, 2003·Chest·Robert J FarneySteven Rhondeau
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David J DrobesKonstantin Voronin
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
Apr 29, 2014·Sleep Medicine Clinics·Robert Joseph Thomas
Mar 30, 2016·Journal of Pharmacological Sciences·Satoko KimuraAkira Haji
May 10, 2016·Chest·Pierre-Yves OlivierFrédéric Gagnadoux
Oct 22, 2017·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators

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Citations

Dec 24, 2019·Expert Opinion on Drug Safety·Hugo López-PelayoAntoni Gual

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