Severe coagulopathy following intraoperative use of topical thrombin

Annals of Vascular Surgery
Mark R SarfatiSpencer W Galt

Abstract

This report describes a case of severe coagulopathy and bleeding related to the intraoperative use of topically applied thrombin. Commercial thrombin preparations contaminated with bovine factor V have been shown to stimulate the production of antibodies directed against factor V. These antibodies can cause coagulopathy. Our patient developed antibodies against factor V after intraoperative exposure to topical thrombin. The resulting antibody-mediated depletion of factor V caused a severe and refractory coagulopathy. Vascular surgeons should be aware that the use of topical bovine thrombin can cause severe coagulopathy.

References

Feb 1, 1986·The Journal of Clinical Investigation·M E NesheimE J Bowie
Feb 21, 2002·Journal of Vascular Surgery·David G NeschisWilliam R Flinn

❮ Previous
Next ❯

Citations

Sep 24, 2008·Patient Safety in Surgery·Aryeh Shander, Mazyar Javidroozi
Mar 20, 2008·Patient Safety in Surgery·Matthew W ReynoldsSrinath Samudrala
Sep 8, 2009·Patient Safety in Surgery·Christopher Lomax
Aug 27, 2009·Biologics : Targets & Therapy·Wesley K Lew, Fred A Weaver
Sep 13, 2008·Expert Review of Molecular Diagnostics·Sheila M CreanMatthew W Reynolds
Jun 14, 2008·Current Medical Research and Opinion·John ClarkMatthew W Reynolds
Oct 16, 2013·Journal of the American Academy of Dermatology·Nicole Howe, Basil Cherpelis
Jan 17, 2012·Biologicals : Journal of the International Association of Biological Standardization·Ivo LaidmäeRaivo Uibo
Jul 4, 2009·Biomaterials·Giuseppe Intini
May 2, 2009·The Urologic Clinics of North America·Jeffery C Wheat, J Stuart Wolf
May 19, 2009·Clinical Therapeutics·Frederick A OfosuMatthew W Reynolds
Feb 27, 2009·Clinical Therapeutics·Christine M ChengSteven R Kayser
Jul 11, 2009·The Journal of Surgical Research·Sheila CreanMatthew W Reynolds
Jun 30, 2009·Pharmacotherapy·Christopher Lomax, Oren Traub
Jun 30, 2009·Pharmacotherapy·Bradley A Boucher, Oren Traub
Jun 30, 2009·Pharmacotherapy·Joseph J Naoum
Apr 22, 2008·Transfusion·William D Spotnitz, Sandra Burks
Nov 3, 2010·AORN Journal·Deborah J NeveleffChristine S Schulman
Jan 16, 2008·Journal of Biomaterials Applications· Hee Soon ChoMyun-Whan Ahn
Jun 16, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis· He ZhuJawed Fareed
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Abdel TerrabJawed Fareed
May 26, 2009·Patient Safety in Surgery·Paul NessUNKNOWN Recognition, Evaluation and Treatment of Acquired Coagulopathy Consensus (RETACC) Panel
Jun 23, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael Gabay
Apr 8, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·David G GreenhalghW Allan Alexander
Dec 17, 2009·Annals of Surgery·Hardean E AchneckJeffrey H Lawson
Feb 26, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kevin N FosterDaniel M Caruso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Jeanine M WalengaHarry L Messmore
© 2021 Meta ULC. All rights reserved