Severe community-acquired pneumonia

Current Opinion in Critical Care
Francisco Alvarez-Lerma, A Torres

Abstract

Community-acquired pneumonia remains a prevalent and potentially life-threatening infection. In general, the disease is considered severe when inpatient care including ICU admission is required, and this often suggests a poorer prognosis. Severe community-acquired pneumonia continues to be an important subject of research from different perspectives, including assessment of illness severity, etiology, diagnostic tests, and treatment options. The aim of this descriptive review is to comment on the results of the relevant original articles in this area published since April 1, 2003. The main themes in the literature covered by the review include the time course of serum concentrations of different markers of the inflammatory response, validation of severity scores to optimize hospital and ICU admission, outcome improvement (duration of therapy and optimal dosing, time to antibiotic administration, adequate initial treatment, and the impact of positive microbiological diagnosis on management and prognosis), and the efficacy of new antimicrobials. The usefulness of inflammatory markers to assess the outcome of the disease is unclear. Data on severity scores are conclusive and different validated and simple predictive rules are avai...Continue Reading

References

Jan 23, 1997·The New England Journal of Medicine·M J FineW N Kapoor
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G BartlettM J Fine
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Oct 20, 2001·Thorax·UNKNOWN British Thoracic Society Standards of Care Subcommittee on Pulmonary Rehabilitation
Apr 12, 2003·Current Opinion in Pulmonary Medicine·Julie AndrewsNandini Shetty
May 8, 2003·Current Opinion in Infectious Diseases·Jorge RoigMaria L Pedro-Botet
May 8, 2003·Current Opinion in Infectious Diseases·Jan Jelrik OosterheertAndy I M Hoepelman
Jun 13, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evangelos BalisLoukia Zerva
Aug 20, 2003·Internal Medicine·Masaru SuzukiKenji Kobayashi
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lala M DunbarJames B Kahn
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Silvia Fernández-SerranoFrederic Manresa
Sep 13, 2003·Chest·Alessandro Brunelli, Aroldo Fianchini
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kanokporn MongkolrattanothaiRobert S Daum
Nov 7, 2003·Critical Care Clinics·Vladimir Kaplan, Derek C Angus
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN Infectious Diseases Society of America
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Wei Shen LimCharlotte L Colthorpe
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Miguel Sabrià, Magda Campins
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Felipe Rodríguez de Castro, Antoni Torres
Feb 12, 2004·The Lancet Infectious Diseases·Jean-Paul Janssens, Karl-Heinz Krause
Feb 26, 2004·Drugs & Aging·Anna Maria Ferrara, Anna Maria Fietta
Feb 26, 2004·Paediatric Respiratory Reviews·Nikolaos G Papadopoulos
Mar 17, 2004·Current Opinion in Infectious Diseases·Wei Shen Lim, John T Macfarlane
Mar 17, 2004·Current Opinion in Infectious Diseases·Mark Loeb
May 29, 2004·Current Opinion in Critical Care·Mark Wilkinson, Mark A Woodhead

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Citations

Sep 16, 2006·American Journal of Respiratory and Critical Care Medicine·Pedro P EspañaJosé M Quintana
Mar 4, 2006·Current Opinion in Infectious Diseases·Ana RañóAntoni Torres
Sep 13, 2008·Current Opinion in Critical Care·Maurizia CapuzzoJean-Roger Le Gall
Apr 1, 2008·Expert Review of Respiratory Medicine·Kirsty Buising
Mar 11, 2016·Bioscience Trends·Yun Yu, Aihua Fei

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