Severe COVID-19 in Alzheimer's disease: APOE4's fault again?

Alzheimer's Research & Therapy
Nian XiongZhicheng Lin

Abstract

Challenges have been recognized in healthcare of patients with Alzheimer's disease (AD) in the COVID-19 pandemic, given a high infection and mortality rate of COVID-19 in these patients. This situation urges the identification of underlying risks and preferably biomarkers for evidence-based, more effective healthcare. Towards this goal, current literature review and network analysis synthesize available information on the AD-related gene APOE into four lines of mechanistic evidence. At a cellular level, the risk isoform APOE4 confers high infectivity by the underlying coronavirus SARS-CoV-2; at a genetic level, APOE4 is associated with severe COVID-19; at a pathway level, networking connects APOE with COVID-19 risk factors such as ACE2, TMPRSS2, NRP1, and LZTFL1; at a behavioral level, APOE4-associated dementia may increase the exposure to coronavirus infection which causes COVID-19. Thus, APOE4 could exert multiple actions for high infection and mortality rates of the patients, or generally, with COVID-19.

References

Aug 4, 2009·Future Lipidology·Elena Posse de Chaves, Vasanthy Narayanaswami
Oct 29, 2010·Nature·Gonçalo R AbecasisGil A McVean
Sep 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel M Michaelson
Apr 14, 2016·American Journal of Respiratory Cell and Molecular Biology·Xianglan YaoStewart J Levine
Jul 2, 2016·Acta Neuropathologica Communications·Emanuele BraiLavinia Alberi
Nov 25, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter CroninPaula Desplats
Jan 5, 2019·Computational Biology and Chemistry·Md Rezanur RahmanMohammad Ali Moni
Apr 21, 2019·Molecular Neurobiology·Bart Van GoolAnton J M Roebroek
May 28, 2019·Journal of Alzheimer's Disease : JAD·Yahui WuFang Liu
Nov 27, 2019·PloS One·Sun-Jung ChoYoung Ho Koh
Feb 23, 2020·Neurobiology of Disease·Ana B Martínez-MartínezJose M Arbones-Mainar
Mar 18, 2020·Acta Neuropsychiatrica·Anisa Chowdhury, Anto P Rajkumar
May 27, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chia-Ling KuoDavid Melzer
Jun 20, 2020·The New England Journal of Medicine·UNKNOWN Severe Covid-19 GWAS GroupTom H Karlsen
Aug 19, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katrine L RasmussenRuth Frikke-Schmidt
Sep 15, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daniela CamporezFlavia de Paula
Oct 22, 2020·Science·Ludovico Cantuti-CastelvetriMikael Simons
Oct 30, 2020·International Journal of Molecular Sciences·Ik Dong YooJong-Seok Moon
Dec 9, 2020·Journal of Alzheimer's Disease : JAD·Nanyang LiuHao Li
Dec 12, 2020·Nature·Erola Pairo-CastineiraJ Kenneth Baillie
Jan 16, 2021·Cell Stem Cell·Cheng WangYanhong Shi
Feb 12, 2021·International Journal of Molecular Sciences·Qiyue DingYuichiro J Suzuki
Feb 17, 2021·Molecular Psychiatry·Zhicheng Lin

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Citations

Oct 16, 2021·Molecular Psychiatry·Maarten E A ReithZhicheng Lin

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