Severe depletion in liver glutathione during physical exercise

Biochemical and Biophysical Research Communications
S PykeA Quintanilha

Abstract

Physical exercise at submaximal levels in rats results in a progressive depletion of liver glutathione to about 20% of the levels found in sedentary controls which persists for several hours following the cessation of exercise. Skeletal muscle appears to be spared this severe depletion phenomenon. The levels of plasma glutathione show a transient increase at the beginning of the exercise bout followed by a linear decrease with increased running time of the animals. These results may be particularly relevant when attempting to understand the effects of physical exercise on a large number of cellular and organismal functions that are known or suspected to depend critically on the glutathione status of the liver.

References

Oct 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J D SunR F Henderson
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·N KaplowitzM Ookhtens
Aug 15, 1985·Archives of Biochemistry and Biophysics·G T SáezJ Viña
Aug 31, 1982·Biochemical and Biophysical Research Communications·K J DaviesL Packer
Sep 1, 1984·The American Journal of Sports Medicine·C Tudisco, G Puddu
Apr 29, 1983·Science·A Meister
Jun 1, 1983·Experimental and Molecular Pathology·A Salminen, V Vihko
May 15, 1981·Experientia·J FridénB Ekblom

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Citations

Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·P C MillsD J Marlin
Jan 1, 1991·European Journal of Drug Metabolism and Pharmacokinetics·H Lew, A Quintanilha
Dec 1, 1991·Pharmacology & Therapeutics·L D DeLeve, N Kaplowitz
Oct 1, 1992·Free Radical Biology & Medicine·G Barja de Quiroga
Jun 1, 1995·Free Radical Biology & Medicine·L L Ji
Mar 1, 1994·Free Radical Biology & Medicine·W G SiemsR Brenke
Jan 29, 2003·Life Sciences·Ken-ichiro MinatoToshihiko Osawa
Jul 24, 2002·Scandinavian Journal of Medicine & Science in Sports·Mustafa GulOsmo Hänninen
Aug 7, 2012·Antioxidants & Redox Signaling·Katia AquilanoMaria R Ciriolo
Jun 11, 2004·Annual Review of Nutrition·Siobhan E Moriarty-Craige, Dean P Jones
Feb 1, 1997·Aging : Clinical and Experimental Research·R A Fielding, M Meydani
May 1, 1993·Acta Physiologica Scandinavica·C K SenO Hänninen
Feb 26, 2016·Free Radical Biology & Medicine·Shaun A MasonGlenn D Wadley
Mar 14, 2000·Redox Report : Communications in Free Radical Research·D E LaaksonenC K Sen
Dec 1, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A-K Sohlenius-Sternbeck, S Schmidt
Feb 17, 2015·Journal of the International Society of Sports Nutrition·Wataru AoiAkane Higashi
Aug 2, 2016·Oxidative Medicine and Cellular Longevity·Sergio Di MeoVictor Manuel Victor
Dec 23, 1998·Critical Reviews in Toxicology·A Löf, G Johanson
Dec 19, 1998·Cell Biochemistry and Function·S D Balakrishnan, C V Anuradha
Nov 1, 1989·Basic Research in Cardiology·S F BauerJ C Rüegg
Jul 23, 1999·Medicine and Science in Sports and Exercise·S K PowersC Leeuwenburgh
Dec 1, 1988·The American Journal of Physiology·J M EstrelaJ Viña
Jan 15, 2008·Free Radical Biology & Medicine·Sean Sachdev, Kelvin J A Davies

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