[Severe drug hepatitis caused by Chelidonium].

Der Internist
K RifaiC Trautwein

Abstract

We report the case of a 58-year-old male patient who was admitted with severe acute cholestatic hepatitis. Liver biopsy showed signs of drug-induced hepatitis. Other causes of acute hepatitis were excluded. Therefore, the ingestion of a Chelidonium-containing preparation (celandine) was thought to be responsible for the hepatitis. Shortly after stopping the administration of Chelidonium, the highly pathological levels of several liver parameters began to normalise. As no autoantibodies were detectable, an idiosyncratic reaction as the cause of drug-induced hepatitis is probable. In cases of unknown hepatitis, herbal medications should be taken into account as a possible cause.

References

Aug 1, 1986·Annals of Internal Medicine·N H ShearW Kalow
Jan 1, 1997·Journal of Hepatology·P H Beaune, S Lecoeur
Oct 27, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M P Manns, P Obermayer-Straub
Oct 27, 1999·Gastroenterology·J BenningerE G Hahn
Jun 11, 2003·Scandinavian Journal of Gastroenterology·F StickelD Schuppan

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Citations

Apr 29, 2009·Journal of Ethnopharmacology·Paola A MoroCarmela Santuccio
Aug 30, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Rolf TeschkeAxel Eickhoff
Sep 7, 2011·Regulatory Toxicology and Pharmacology : RTP·Rolf TeschkeJohannes Schulze
Mar 1, 2012·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Barbara SarterPratip Banerji
Apr 30, 2016·International Journal of Molecular Sciences·Christian Frenzel, Rolf Teschke
Jul 13, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amy Christine Brown
Jun 6, 2009·Der Internist·K WerdanU Müller-Werdan

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