Severe enteropathy with villous atrophy in prolonged mefenamic acid users - a currently under-recognized in previously well-recognized complication: Case report and review of literature

Medicine
Uayporn KaosombatwattanaPhunchai Charatcharoenwitthaya

Abstract

Mefenamic acid-induced enteropathy may be an under-recognized condition because few reported cases and no review of literature to comprehensively describe all reported cases exist. From inception until February 2017, a systematic literature search identified twenty original reports of cases of mefenamic acid-induced enteropathy. Additional five cases were identified at our hospital. All cases were included in the analyses. Most patients had been regularly taking therapeutic dosages of mefenamic acid for at least three months before symptoms developed. All patients presented with chronic diarrhea with significant weight loss. Approximately one-third of the cases had some degree of anemia and hypoalbuminemia. Endoscopic findings could range from very mild abnormalities, such as mild atrophic mucosa, to marked abnormalities, such as blunted villi with scalloping appearance in the small intestine and inflamed mucosa with a few superficial ulcers in the ileum and colon. Pathological findings included flattened small intestinal villi and mixed inflammatory infiltrates including eosinophils in lamina propria. After identifying history of prolong mefenamic acid exposure, all patients were prescribed to stop this medication. Nutritional...Continue Reading

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Citations

Jun 12, 2018·Expert Review of Gastroenterology & Hepatology·Stefania Chetcuti ZammitReena Sidhu
Dec 18, 2018·European Journal of Gastroenterology & Hepatology·Annalisa SchiepattiFederico Biagi
Apr 14, 2020·European Journal of Gastroenterology & Hepatology·Annalisa SchiepattiFederico Biagi
Sep 4, 2018·La Revue de médecine interne·A SadkiI Marie

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biopsy

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