Severe Extravasation Injuries in Neonates: A Report of 34 Cases

Pediatric Dermatology
Nikolaos KostogloudisNikolaos Nikolaidis

Abstract

Extravasation injuries are a common and challenging problem in hospitalized newborns. Accidental infusion leakage into the surrounding tissues in immature infants may frequently result in skin necrosis, with significant risk of functional and cosmetic impairment. In the present study we reviewed 34 cases of severe extravasation injuries occurring in 1,409 neonates hospitalized in a single neonatal unit over 24 months (incidence 2.4%). Total parenteral nutrition solutions were involved in most cases. All patients were treated within 30 minutes after the injury was recorded using a flush-out technique with normal saline irrigation and occlusive paraffin dressings of the infiltrated area. The majority of injuries affected preterm, low-birthweight infants (mean gestation 32 wks + 6 days, mean birth weight 1,885 g), with a mean age at the time of injury of 11.6 days and a mean weight of 2,045 g. Neither gestational age (p = 0.87) or birthweight significantly affected (p = 0.07) the incidence of extravasation injuries, although the incidence of skin necrosis had a significant correlation with gestational age (p = 0.009) and birthweight (p < 0.001). All patients responded well to treatment and their wounds healed uneventfully within a...Continue Reading

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Citations

Jul 21, 2017·The Cochrane Database of Systematic Reviews·P N GopalakrishnanSujoy Banerjee
Nov 15, 2017·The Journal of Craniofacial Surgery·Eric D VillarrealDerek M Kelly
Feb 28, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Thomas A HoovenRichard A Polin
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Aug 24, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Amber G Fessler, Catherine E Rejrat

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