Severe fatty liver in rats fed a fat-free ethanol diet, and its prevention by small amounts of dietary arachidonate

Lipids
S C GoheenG A Rao

Abstract

Rats were fed ethanol and a fat-free diet for 30 days to determine whether dietary fat is needed for the development of fatty liver. The severity of fatty liver was similar to that of rats fed an isocaloric diet with 35% fat. Small amounts (29 mg/day) of dietary arachidonic acid prevented alcoholic fatty liver. Rats fed either the alcohol (AF) or control (CF) fat-free diets developed essential fatty acid deficiency (EFAD) as measured by the triene/tetraene ratio of liver and plasma lipids. Rats fed arachidonic acid (AA, alcohol and CA, control diets) did not develop EFAD. Although EFAD alone did not cause the development of fatty liver, the combination of dietary ethanol and EFAD did. The ratios of 16:1/16:0 and 18:1/18:0 in liver lipids indicated that desaturase enzymes were less active and lipogenesis was reduced in rats fed the AA diet compared to those fed the AF diet. In contrast, stimulated lipogenesis appears to have been the cause of fatty liver in rats fed the AF diet.

References

Jun 1, 1975·Lipids·M E de TomasP Peluffo
Apr 1, 1970·The American Journal of Clinical Nutrition·C S Lieber, L M DeCarli
May 1, 1968·Biochimica Et Biophysica Acta·A J Sinclair, F D Collins

❮ Previous
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Citations

Mar 1, 1985·Prostaglandins, Leukotrienes, and Medicine·D J SegarnickJ Rotrosen
Sep 1, 1993·Baillière's Clinical Gastroenterology·K J Simpson, T J Peters
Nov 27, 2008·Minerva medica·M C HjelkremS A Harrison
May 1, 2013·Critical Reviews in Food Science and Nutrition·Anthony Fardet, Jean-Michel Chardigny
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Hendrik A MarsmanThomas M van Gulik
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ian P J AlwaynMark Puder
Jan 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P L BiagiA Bordoni
Mar 1, 1985·Alcoholism, Clinical and Experimental Research·G Y Sun, A Y Sun
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TsukamotoC Largman
Jul 1, 1987·Biochemical Pharmacology·B E Leonard
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·D F Horrobin
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·A WolkinJ Rotrosen
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·A Gómez-TubíoO Carreras
Jan 22, 2009·Journal of the American College of Nutrition·Melania MancoValerio Nobili
Aug 9, 2007·The American Journal of Clinical Nutrition·Angela M ZivkovicArun J Sanyal
Jun 22, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M OkitaK Suzuki

❮ Previous
Next ❯

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