Severe hepatitis with autoimmune features following a HHV-6: a case report.

Cases Journal
Pierfrancesco GrimaPiero Grima

Abstract

HHV-6 has been identified as the aetiologic agent of exanthem subitum in infants and an acute febrile illness in young children. HHV-6 probably remains latent in the body after the primary infection and it reactivates upon host immunosuppression in a manner similar to other human herpes viruses. Primary HHV-6 infection in adults is very rare and it is not clear whether disease manifestations are similar to those observed in children.We report the case of acute hepatitis in a 18-year-old immunocompetent woman presenting with sever jaundice and liver dysfunction. Serum immunoglobulin levels were elevated (3.8 gr/dl) with a titre of anti nucleus antibody of 1:640. Serological data demonstrated the presence of IgM antibodies against human herpesvirus-6 in the serum and of viral DNA on liver biopsy by real time quantitative polymerase chain reaction, with a viral load of 280 genomes/106 of cellular genomes. No other etiologic agents were found to induce hepatitis and the patient was diagnosed as having HHV-6 triggered autoimmune acute hepatitis.

References

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Citations

Jun 6, 2012·International Journal of Hepatology·Joshua C PritchettManuela G Neuman
Oct 29, 2013·Future Virology·Lorenzo DagnaPaolo Lusso
Jan 9, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Angella Charnot-KatsikasMichael Z David
Apr 8, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Vanessa Salete de PaulaMarcelo Alves Pinto
Nov 28, 2013·TheScientificWorldJournal·Francesco BroccoloLuca Ceccherini-Nelli
Oct 4, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A SultanovaM Murovska
Dec 22, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Laura-Patricia LlovetMaría-Carlota Londoño

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Methods Mentioned

BETA
biopsy

Related Concepts

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Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

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