PMID: 9436758Jan 22, 1998Paper

Severe hyperglycemia in an HIV clinic: preexisting versus drug-associated diabetes mellitus

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
J M Kilby, P B Tabereaux

Abstract

We determined the frequency and clinical nature of severe hyperglycemia in a university clinic for HIV-1-infected patients. The medical records of 1392 adult HIV-infected patients were reviewed for cases of severe hyperglycemia, defined as two or more serum glucose values >250 mg/dl or diabetes treatment during clinic care. Demographic information, family histories of diabetes mellitus, body weights, CD4+ lymphocyte counts, and use of corticosteroids, megestrol acetate, pentamidine, or didanosine were recorded for subjects meeting the case definition. Comparisons were made between preexisting diabetic (group 1) and incident hyperglycemic cases (group 2). Less than 2% of the total clinic population experienced severe hyperglycemia: 12 in group 1 and 13 in group 2. Group 2 had lower body weights (mean, 70.6 kg versus 90.0 kg; p < 0.05) and more advanced HIV disease (mean CD4 count, 79/mm3 versus 550/mm3; p < 0.05) than group 1. Group 2 cases had evidence of drug-associated hyperglycemia; four cases demonstrated hyperglycemia coinciding with large fluctuations in weight during megestrol therapy. Among megestrol recipients, cases did not differ from noncases in demographics, weight, or CD4 count. Severe hyperglycemia is uncommon in...Continue Reading

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Citations

Dec 17, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cecilia YoonMarshall J Glesby
Feb 19, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katherine Samaras
Mar 19, 2013·BMC Infectious Diseases·Davis KibirigeWilliam Worodria
Nov 6, 2015·Journal of Renal Care·Christine Skouberdis Smith, John V Logomarsino
Jun 22, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B Max, R Sherer
Jun 11, 2003·The Nurse Practitioner·Michael D Greene
May 5, 2001·Expert Opinion on Pharmacotherapy·S Kravcik
May 14, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Melissa HerrinAmy C Justice
Oct 9, 2018·Current Diabetes Reports·Emile Camille NoubissiEugene Sobngwi
Mar 23, 2001·The Annals of Pharmacotherapy·H HardyG D Morse
Jun 12, 1999·Journal of Cutaneous Medicine and Surgery·K SmithH Skelton
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M P Dubé
Nov 30, 1999·Annals of Internal Medicine·Z T MadhunG A McComsey

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