PMID: 3718111Jun 1, 1986

Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

Archives of Internal Medicine
E R Swenson

Abstract

Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation.

Citations

Jan 1, 1987·Journal of Ocular Pharmacology·F T Fraunfelder, S M Meyer
Jan 1, 1990·Journal of Ocular Pharmacology·G C ChiouB H Li
Mar 1, 1991·The British Journal of Ophthalmology·Y Wakabayashi
Jul 23, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Chaker Ben SalemHoussem Hmouda
Jan 6, 2005·American Heart Journal·Kamala P TamirisaTodd M Koelling
Feb 16, 1991·BMJ : British Medical Journal·F HartveitJ Christensen
Dec 24, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F HintenJ A de Hullu

Related Concepts

Glaucoma
Hyperkalemia
Ophthalmic Solution
Experimental Lung Inflammation
Potassium
Rectodelt
Radiation Syndrome
Timoptol

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