PMID: 8986990Dec 1, 1996Paper

Severe hypertension and cardiac failure associated with neuroblastoma: a case report

Journal of Pediatric Surgery
D SendoK Hayasaka

Abstract

The authors report on 3-year-old-girl with neuroblastoma complicated by severe hypertension and cardiac failure. She had cardiomegaly and pleural and pericardial effusions. Echocardiogram showed left ventricular hypertrophy and decrease of the left ventricular ejection fraction to 0.36 (normal > .40). Abdominal computed tomographic scan indicated a 7 x 7-cm tumor in the left suprarenal area. There was a marked increase in catecholamines and metabolites in her body fluids. After hypertension was controlled with doxazosin (a long-acting alpha 1 adrenergic blocker), her cardiac function gradually improved. A tumor was surgically removed and diagnosed as a poorly differentiated ganglioneuroblastoma. Preoperative differentiation between neuroblastoma and pheochromocytoma was not possible on the basis of catecholamine analysis or imaging studies including computed tomography scan and magnetic resonance imaging. It is important to control hypertension quickly in the patients with catecholamine-induced cardiomyopathy to facilitate surgical intervention for diagnosis and treatment.

Citations

Apr 22, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas R LatendresseChrister Jonmarker
Oct 12, 2005·Journal of Pediatric Hematology/oncology·Mohammad Ali EhsaniLeila Kohan
Jul 1, 2010·Pediatric Blood & Cancer·Peter CarlsonHeidi Russell
Aug 30, 2005·The Journal of Pediatrics·Harinder R SinghMark V Zilberman
Jun 18, 2005·Paediatric Anaesthesia·Christian SeefelderRobert C Shamberger
Dec 19, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Jun FujishiroTadashi Iwanaka
Nov 28, 2006·Endocrinology and Metabolism Clinics of North America·Frederieke M BrouwersKarel Pacak
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Oct 27, 2006·Pediatric Blood & Cancer·M KatoR Hanada
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Dec 6, 2019·Journal of Travel Medicine·Bradley A ConnorDavidson H Hamer

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