Severe hypertriglyceridemia and acute pancreatitis during pregnancy: treatment with gemfibrozil.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
H F SaadiB J Hoogwerf

Abstract

To describe the effect of gemfibrozil therapy during pregnancy in a woman with severe hypertriglyceridemia. We present a case report, with details of lipid levels throughout several attempted pregnancies, and discuss other similar published studies. In a 22-year-old woman, severe acute pancreatitis due to hypertriglyceridemia developed during her first pregnancy. After a prolonged hospital course, the outcome was fetal demise. The patient was subsequently treated with gemfibrozil, which controlled the hypertriglyceridemia. A second pregnancy ended with a therapeutic abortion at 1 month because of the possible risk of pancreatitis. Gemfibrozil therapy was instituted but subsequently discontinued when she was discovered to be pregnant again, at approximately 10 weeks of gestation; the potential risks involved with the use of this drug during pregnancy were unknown. Because of the patient's strong desire to maintain the pregnancy, gemfibrozil treatment was resumed 1 week later in order to help prevent recurrent pancreatitis. The patient ultimately delivered a fullterm healthy boy, and she had no recurrence of pancreatitis or other complications. In selected patients at high risk for pancreatitis, the potential risk of gemfibrozil ...Continue Reading

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Citations

Mar 4, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·C HuissoudA Levrat
Apr 5, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Claudia StefanuttiClaudia Morozzi
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May 14, 2021·Journal of Atherosclerosis and Thrombosis·Hiroaki OkazakiMariko Harada-Shiba

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