Severe hypertriglyceridemia : Diagnostics and new treatment principles

Der Internist
U KassnerE Steinhagen-Thiessen

Abstract

Severe hypertriglyceridemia is defined at a plasma triglyceride (TG) concentration of >885 mg/dl and may result - in particular when clinical symptoms appear before the age of 40 - from "large variant" mutations in genes which influence the function of the lipoprotein lipase (LPL). For diagnosis, secondary factors have to be excluded and treated before further genetic tests are considered. Typical symptoms in almost all patients are recurrent, sometimes severe abdominal pain attacks, which can result in acute pancreatitis, the most important, sometimes life-threatening complication. To minimize the risk of severe pancreatitis, the aim is to maintain the plasma TG concentration <1000 mg/dl. Other clinical manifestations which can occur and are reversible are eruptive xanthomas, lipemia retinalis, hepatosplenomegaly, dyspnea syndrome, and impaired neurocognitive function. The hyperviscosity syndrome caused by chylomicronemia is seen as the underlying reason for some of the symptoms. Patients with mild-to-moderate hypertriglyceridemia have an increased cardiovascular risk. To lower this is the primary treatment goal here. Treatment mainly consists of a life-long, strict fat- and carbohydrate-restricted diet and the abstention from...Continue Reading

References

Nov 10, 1998·Circulation·B StaelsJ C Fruchart
Apr 11, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·George YuanRobert A Hegele
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Sandeep BansalPaul M Ridker
Nov 13, 2007·Nature Genetics·Miklós PéterfyMark H Doolittle
Nov 13, 2008·JAMA : the Journal of the American Medical Association·Jacob J FreibergBørge G Nordestgaard
Aug 13, 2010·The New England Journal of Medicine·Christoph H SaelyHeinz Drexel
Sep 17, 2010·The New England Journal of Medicine·William J Perkins
Feb 15, 2011·Current Vascular Pharmacology·Børge G Nordestgaard, Jacob J Freiberg
Nov 17, 2011·The New England Journal of Medicine·William E BodenWilliam Weintraub
Mar 23, 2012·The Journal of Clinical Endocrinology and Metabolism·André C CarpentierDaniel Gaudet
Jun 14, 2012·Current Opinion in Lipidology·Daniel GaudetJohn Kastelein
Sep 13, 2012·JAMA : the Journal of the American Medical Association·Evangelos C RizosMoses S Elisaf
Dec 26, 2012·Journal of the American College of Cardiology·Anette VarboBørge G Nordestgaard
Mar 12, 2013·Genes & Development·Stephen G Young, Rudolf Zechner
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Robert A HegeleUNKNOWN European Atherosclerosis Society Consensus Panel
Oct 2, 2014·European Journal of Internal Medicine·Pedro ValdivielsoNils Ewald
Dec 4, 2014·The New England Journal of Medicine·Daniel GaudetJoseph L Witztum
Dec 17, 2014·Journal of the American College of Cardiology·Robert S RosensonDaniel Gaudet
Sep 1, 2015·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Prashant NasaKandy Koul
Sep 24, 2015·International Journal of Surgery·Annika CharlesworthMartin A Crook
Dec 22, 2016·Atherosclerosis. Supplements·Erik StroesMaurizio Averna

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Citations

Feb 24, 2021·The American Journal of the Medical Sciences·Talha M QureshiMohamed O Othman
May 25, 2021·JBJS Case Connector·Alexander PieringerValentin Neuhaus

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