Severe hypoalbuminemia at day 90 predicts worse nonrelapse mortality and overall survival after allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Mohamed A Kharfan-DabajaClaudio Anasetti

Abstract

Because patients who undergo allogeneic hematopoietic cell transplantation (allo-HCT) remain in the vicinity of the transplant center for approximately 90 days posttransplantation, identifying prognostic factors to determine those at immediate higher risk of mortality is essential. A normal serum albumin level generally denotes healthiness. We evaluated the prognostic significance of day 90 hypoalbuminemia (and other clinical, pharmacologic, and laboratory variables) in 163 patients, median age 48 years (range, 19-69 years), who underwent allo-HCT for acute myelogenous leukemia (n = 124) or myelodysplastic syndrome (n = 39). Day 90 hypoalbuminemia (serum albumin <3.0 g/dL) was associated with worse nonrelapse mortality (NRM) and poor overall survival (OS). The estimated 1- and 2-year cumulative incidence rates of NRM were 48% and 52%, respectively, and the corresponding OS rates were 7% and 3%. Serum albumin level <3.0 g/dL and Karnofsky score <80 at day 90 were strong independent predictors of worse NRM and OS in multivariate analysis. These results support day 90 hypoalbuminemia as an adverse prognostic marker for NRM and OS after allo-HCT for acute myelogenous leukemia and myelodysplastic syndrome.

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Citations

Nov 1, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Panagiotis TsirigotisAchilles Anagnostopoulos
Oct 24, 2012·American Journal of Hematology·Rami S KomrokjiAlan F List
Apr 12, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jennifer E VaughnMohamed L Sorror
Sep 29, 2011·Seminars in Oncology·Simrit ParmarRichard Champlin
Nov 19, 2019·Pediatric Blood & Cancer·Thomas Williams McLeanJanet Austin Tooze
Mar 4, 2021·European Journal of Haematology·Megan MelodyMohamed A Kharfan-Dabaja
Aug 12, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rashmika PotdarRoni Shouval

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