Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection

Diabetes/metabolism Research and Reviews
U Pedersen-BjergaardB Thorsteinsson

Abstract

Differences between studies in rates of severe hypoglycaemia in type 1 diabetic cohorts are common and poorly understood. The purpose of this study was to assess the frequency of severe hypoglycaemia in unselected patients treated in different secondary care centres and to evaluate the influence of risk markers, clinical setting and selection. Cross-sectional Danish-British multicentre survey of 1076 consecutive adult patients with clinical type 1 diabetes who completed a detailed questionnaire on hypoglycaemia and related issues. Key variable was the self-reported rate of severe hypoglycaemia during the preceding year. The overall rate of severe hypoglycaemia in the preceding year was 1.3 episodes/patient-year and episodes were reported by 36.7% of subjects. The distribution was highly skewed with 5% of subjects accounting for 54% of all episodes. There were no significant differences between countries or centres. Reduced hypoglycaemia awareness, peripheral neuropathy and smoking were the only significant risk markers of severe hypoglycaemia in a stepwise multivariate analysis. In a subgroup selected to be similar to the Diabetes Control and Complications Trial (DCCT) cohort, the rate of severe hypoglycaemia was 0.35 episodes/...Continue Reading

Associated Clinical Trials

Nov 18, 2011·Michael R. Rickels, MD, MS
Apr 22, 2015·Ibragimova Lyudmila, Ibragimova Lyudmila

References

Apr 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·S PrammingC Binder
Sep 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·D A HepburnB M Frier
Feb 1, 1983·Diabetologia·C GoldgewichtG Tchobroutsky
Jan 1, 1994·Journal of Applied Physiology·S R ColbergG A Brooks
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Apr 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·K M MacLeodB M Frier
Dec 30, 1998·Journal of Neural Transmission·R DuelliW Kuschinsky
Apr 13, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·S R Heller
Oct 27, 2001·Diabetes Care·C AllenUNKNOWN Wisconsin Diabetes Registry Project
Mar 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Thomas B PriceDouglas L Rothman
Jun 6, 2003·Diabetes/metabolism Research and Reviews·Ulrik Pedersen-BjergaardBirger Thorsteinsson

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Citations

Jul 6, 2012·Current Diabetes Reports·Michael R Rickels
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Edmond A Ryan, Am James Shapiro
Jun 11, 2010·Diabetes Technology & Therapeutics·Henry Anhalt, Nancy J V Bohannon
Nov 20, 2012·Family Practice·Alexander SämannUlrich A Müller
Jan 15, 2008·Transplantation·Rainer W G GruessnerAngelika C Gruessner
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Michael McCall, A M James Shapiro
Jan 4, 2013·Diabetes Care·Daniel LorberAlan L Yatvin
Oct 17, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Veronika KrnacovaJiri Vlcek
Jun 23, 2010·European Journal of Endocrinology·P L KristensenB Thorsteinsson
Dec 20, 2011·Diabetes Management·Linda Gonder-FrederickWilliam Clarke
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·Sanjay KalraAmbady Ramachandran
Feb 12, 2014·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Domingo Orozco-BeltránManuel Galán
Oct 8, 2014·Nature Reviews. Endocrinology·Brian M Frier
Jun 18, 2011·Postgraduate Medicine·Jeff Unger, Christopher Parkin
Dec 17, 2009·Journal of Medical Economics·Mette HammerBrian M Frier
May 27, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Katsuhisa MatsuuraTeruo Okano
Nov 2, 2015·Cellular and Molecular Life Sciences : CMLS·Hanne M M RooijackersBastiaan E de Galan
May 23, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·A-S SejlingU Pedersen-Bjergaard
Nov 27, 2009·Diabetes Research and Clinical Practice·Josefine E SchopmanBrian M Frier
Sep 29, 2009·Primary Care Diabetes·Alex J Graveling, Brian M Frier
Oct 3, 2009·Journal of Diabetes and Its Complications·Thomas Høi-HansenBirger Thorsteinsson
Jun 6, 2009·Diabetes Research and Clinical Practice·M V HansenB Thorsteinsson
May 12, 2009·Transplant Immunology·Bernhard J Hering, Niketa Walawalkar
Feb 4, 2009·Diabetes Research and Clinical Practice·L Ringholm NielsenE R Mathiesen
Aug 23, 2005·Diabetes/metabolism Research and Reviews
Jun 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·T Høi-HansenB Thorsteinsson
Jul 23, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·L Ringholm NielsenE R Mathiesen
Dec 20, 2007·Diabetes/metabolism Research and Reviews·Brian M Frier
Sep 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·N N ZammittB M Frier
Apr 5, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·J GeddesB M Frier

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