PMID: 11544612Sep 7, 2001Paper

Severe hypoglycaemia in patients with type 1 diabetes and impaired awareness of hypoglycaemia: a comparative study of insulin lispro and regular human insulin

Diabetes/metabolism Research and Reviews
S C FergusonBrian M Frier

Abstract

To assess the potential of insulin lispro to limit the frequency of severe hypoglycaemia without compromising glycaemic control in a cohort of patients with type 1 diabetes who are at a high risk of severe hypoglycemia. Research design and methods An open-label, randomised, 12-month comparative crossover study of insulin lispro and regular human insulin was performed in 33 patients with type 1 diabetes with impaired hypoglycaemia awareness. The efficacy of each treatment was evaluated by glycaemic control (HbA(1c)), eight-point home blood glucose profiles, and the frequency and severity of hypoglycaemic episodes and quality of life. Eighteen (55%) patients experienced one or more episodes of severe hypoglycaemia in the 48 weeks of study. There was a trend to a lower incidence of severe hypoglycaemia during treatment with insulin lispro in comparison with regular human insulin (55 vs 84 episodes, p=0.087). This resulted principally from a 47% lower incidence of nocturnal severe hypoglycaemia with insulin lispro (25 vs 47 episodes, p=0.11). The lower frequency of severe hypoglycaemia associated with insulin lispro was not explained by differences in glycated haemoglobin between insulin treatments (HbA(1c) 9.1% insulin lispro vs 9...Continue Reading

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Citations

Feb 18, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sumeet R SinghHeather Bennett
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Satoru Yamada
Aug 28, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·C PratoomsootW J Valentine
Jul 2, 2003·Expert Opinion on Pharmacotherapy·Vincent McAulay, Brian M Frier
Oct 31, 2017·Current Diabetes Reports·Ulrik Pedersen-Bjergaard, Birger Thorsteinsson
Jul 1, 2016·The Cochrane Database of Systematic Reviews·Birgit FullertonFerdinand M Gerlach
Dec 18, 2018·The Cochrane Database of Systematic Reviews·Birgit FullertonFerdinand M Gerlach
Oct 22, 2002·Nihon rinsho. Japanese journal of clinical medicine·Ayako Matsuda
Apr 21, 2006·The Cochrane Database of Systematic Reviews·A SiebenhoferT R Pieber
Dec 25, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Antonio NicolucciMarco Orsini Federici
Oct 31, 2002·PharmacoEconomics·Christopher J Dunn, Greg L Plosker
Jan 13, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kate V Allen, Brian M Frier

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