PMID: 2491424Nov 1, 1989Paper

Severe hypoglycemia in children with insulin-dependent diabetes mellitus: frequency and predisposing factors

The Journal of Pediatrics
D DanemanR Ehrlich

Abstract

We surveyed 311 children with insulin-dependent diabetes mellitus to evaluate the frequency and characteristics of those children experiencing severe hypoglycemia (defined by an episode of coma, convulsion, or both). The children and their parents completed a questionnaire, and we reviewed the hospital records to confirm reported episodes. Ninety-seven (31%) reported severe hypoglycemia, and a further 50 (16%) reported moderate hypoglycemia requiring the assistance of another person but not resulting in coma or convulsion. In 164 children (53%) there was no history of either moderate or severe hypoglycemia. Sixty-nine (22%) reported the occurrence of more than one severe hypoglycemic episode (range 2 to 20); 52 (16%) reported such an event in a single year. A total of 285 episodes were reported, 39% during sleep and 61% while awake. Children reporting such events tended to have diabetes of longer duration and be younger at the time of the first episode. Hemoglobin A1c concentration at the time closest to the severe episode was significantly lower than in children reporting no hypoglycemia. All families had been taught to use glucagon to reverse severe hypoglycemia at home, but it was available in only 80 of the 97 homes and use...Continue Reading

Citations

Jul 1, 1993·Baillière's Clinical Endocrinology and Metabolism·G Soltész
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·D J Becker, C M Ryan
Jun 14, 2013·Diabetes Technology & Therapeutics·Takashi MurataNaoki Sakane
Nov 18, 2008·Journal of Paediatrics and Child Health·Michele A O'ConnellFergus J Cameron
Jul 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·J P Shield, J D Baum
Jul 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·T SimellJ Mäenpää
Jul 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·R H DumontD Wertlieb
Apr 9, 1999·Acta Paediatrica. Supplement·F ChiarelliL Pinelli
Dec 1, 1991·Archives of Disease in Childhood·L BarkaiI Vámosi
May 16, 2014·Canadian Journal of Diabetes·UNKNOWN Canadian Diabetes Association Clinical Practice Guidelines Expert CommitteeJohn Dornan
Nov 1, 1989·The Journal of Pediatrics·L B Travis
Dec 28, 1999·Endocrinology and Metabolism Clinics of North America·C M Ryan, D J Becker
Oct 27, 2001·Diabetes Care·C AllenUNKNOWN Wisconsin Diabetes Registry Project
Mar 19, 2004·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Elina M MattilaLiisa-Maria Voipio-Pulkki
Apr 18, 2015·Annals of Pediatric Endocrinology & Metabolism·Dong Soo KangJeesuk Yu
Feb 15, 2001·Journal of Pediatric Gastroenterology and Nutrition·B RamiE Schober
Dec 19, 2003·Pediatric Research·Kelvin A YamadaDaniel G Herrera
Mar 16, 2004·Pediatric Diabetes·Francine Ratner KaufmanPisit Pitukcheewanont
Dec 6, 2003·Pediatric Diabetes·Timothy W Jones, Elizabeth A Davis
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·N ShehadehA Etzioni
Jan 1, 1999·Paediatrics & Child Health·D DanemanJ Wittenberg
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·E A Davis, T W Jones

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