Severe hypovitaminosis D in active tuberculosis patients and its predictors

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Qiuzhen WangEvert G Schouten

Abstract

Tuberculosis (TB) patients have a significant vitamin D deficiency (VDD) endemic, which may be closely related to the onset and progress of the disease. The comorbidity of diabetes (DM) and TB has posed an increasing challenge in recent years. However, the influence of DM on TB and the possible mechanism are still uncertain. We carried out this study to identify the nutritional status of vitamin D (VD) in TB patients in a northern city in China (latitude 36° N) and investigate the possible predictors of severe vitamin D deficiency (SVDD). A cross-sectional study including 461 active TB patients (192 with and 269 without DM) were randomly selected from Qingdao Chest Hospital from June 2015 to August 2016. We measured serum 25 hydroxyvitamin D [25(OH)D], and investigated the association between sociodemographic, dietary intake, DM, body mass index (BMI), severity of initial TB signs and symptoms (TB score) and VD status. Multivariate logistic regression analysis was used to define the possible predictors of SVDD. The median serum 25(OH)D concentration was 8.50 ng/mL. Of the 461 TB patients included, 383 (83.1%) had VDD [25(OH)D < 20 ng/mL], and 217 (47.1%) had SVDD [25(OH)D < 8 ng/mL]. The variables associated with serum 25(OH)D ...Continue Reading

Citations

Nov 2, 2019·Journal of Nutritional Science and Vitaminology·Qiuzhen WangEvert G Schouten
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Qiyao ChaiCui Hua Liu
Sep 20, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Qiuzhen WangFrans J Kok

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