Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.

JCI Insight
Kenneth E RemyRichard S Hotchkiss

Abstract

COVID-19-associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral dissemination and organ injury. A key explanation for the inability to address this controversy has been the lack of diagnostic tools to evaluate immune function in COVID-19 infections. ELISpot, a highly sensitive, functional immunoassay, was employed in 27 patients with COVID-19, 51 patients with sepsis, 18 critically ill nonseptic (CINS) patients, and 27 healthy control volunteers to evaluate adaptive and innate immune status by quantitating T cell IFN-ɣ and monocyte TFN-α production. Circulating T cell subsets were profoundly reduced in COVID-19 patients. Additionally, stimulated blood mononuclear cells produced less than 40%-50% of the IFN-ɣ and TNF-α observed in septic and CINS patients, consistent with markedly impaired immune effector cell function. Approximately 25% of COVID-19 patients had increased IL-6 levels that were not associated with elevations in other canonical proinflammatory cytokines. Collectively, these findings support the hypothesis that COVID-19 suppresses h...Continue Reading

References

Dec 1, 1996·The Journal of Allergy and Clinical Immunology·S MatsukuraM Adachi
Mar 28, 2009·Critical Care Medicine·Hector R WongUNKNOWN Genomics of Pediatric SIRS/Septic Shock Investigators
Apr 22, 2009·Blood·Irini SeretiUNKNOWN ACTG 5214 Study Team
Jan 24, 2012·Nature Reviews. Immunology·Susan L SwainTara M Strutt
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto
Jul 28, 2016·Shock·Narendra Kumar Sharma, Reinaldo Salomao
Mar 9, 2018·JCI Insight·Bruno FrancoisRichard S Hotchkiss
Sep 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monty MazerKenneth E Remy
Jan 29, 2020·Human Movement Science·Tomohito IjiriToshiaki Suzuki
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Mar 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chuan QinDai-Shi Tian
Mar 17, 2020·International Journal of Antimicrobial Agents·Christian A DevauxDidier Raoult
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 22, 2020·Journal of Clinical Pathology·Brian HanleyMichael Osborn
Mar 24, 2020·Cellular & Molecular Immunology·Meijuan ZhengZhigang Tian
Mar 27, 2020·The New England Journal of Medicine·Richard S Hotchkiss, Steven M Opal
Mar 29, 2020·JAMA : the Journal of the American Medical Association·John D Roback, Jeannette Guarner
Apr 1, 2020·The Journal of Infectious Diseases·Fan WangYongxi Zhang
Apr 2, 2020·Disaster Medicine and Public Health Preparedness·Yun-Jung Kang
Apr 4, 2020·American Journal of Respiratory and Critical Care Medicine·Yingzhen DuGuogang Xu
Apr 4, 2020·Journal of the American Academy of Dermatology·Payal Shah, John G Zampella
Apr 8, 2020·Annals of the American Thoracic Society·Rong-Hui DuHuan-Zhong Shi
Apr 8, 2020·Chemotherapy·Marco CiottiMassimo Ciccozzi
Apr 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiaohua ChenFeng Li
Apr 29, 2020·Journal of the American Academy of Dermatology·Danielle PetersonBrett King
May 1, 2020·The Lancet. Respiratory Medicine·Ricardo J Jose, Ari Manuel
May 1, 2020·The Journal of Experimental Medicine·Santosha A Vardhana, Jedd D Wolchok
May 7, 2020·Annals of Internal Medicine·Dominic WichmannStefan Kluge
May 8, 2020·Autoimmunity Reviews·Piero RuscittiRoberto Giacomelli
May 8, 2020·Annals of the Rheumatic Diseases·Achille AoubaAurélien Justet
May 10, 2020·Science Immunology·Francesca Romana SpinelliMassimo Gadina
May 11, 2020·The Lancet Infectious Diseases·David J M Wright
May 24, 2020·The Lancet. Respiratory Medicine·Kenneth E RemyLyle L Moldawer

❮ Previous
Next ❯

Citations

Aug 7, 2020·American Journal of Respiratory and Critical Care Medicine·James D Chalmers, Sanjay H Chotirmall
Sep 6, 2020·Nature Reviews. Immunology·Mangalakumari JeyanathanZhou Xing
Dec 29, 2020·The European Respiratory Journal·James D Chalmers
Oct 27, 2020·The Journal of Clinical Investigation·Philip A Mudd, Kenneth E Remy
Jan 3, 2021·Journal of Clinical Immunology·Florian ReizineJean-Marc Tadié
Nov 21, 2020·International Journal of Antimicrobial Agents·Roya RamezankhaniCatherine Verfaillie
Nov 4, 2020·Critical Care : the Official Journal of the Critical Care Forum·Mathieu BlotUNKNOWN Pneumochondrie study group
Jan 11, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dennis G MoledinaF Perry Wilson
Nov 27, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monty B MazerRichard S Hotchkiss
Dec 5, 2020·Journal of Translational Medicine·Mathieu BlotUNKNOWN LYMPHONIE study group
Jan 8, 2021·Frontiers in Immunology·Anthony J Leonardi, Rui B Proenca
Feb 11, 2021·Cell Reports Medicine·Marios KoutsakosKatherine Kedzierska
Jan 31, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isaac J JensenVladimir P Badovinac
Feb 23, 2021·Frontiers in Immunology·Margaret A McBrideNaeem K Patil
Feb 23, 2021·Frontiers in Immunology·Charles Ochieng' OlwalSamuel Duodu
Jan 26, 2021·The Journal of Clinical Investigation·Sara Falck-JonesAnna Smed-Sörensen
Mar 16, 2021·Frontiers in Immunology·Dominique MoserTobias Woehrle
Mar 21, 2021·Cell·Joachim L Schultze, Anna C Aschenbrenner
Feb 2, 2021·The Journal of Infectious Diseases·Nico A F JanssenFrank L van de Veerdonk
Mar 23, 2021·Frontiers in Immunology·Holger A LindnerThomas Kirschning
Apr 1, 2021·Critical Care Explorations·Mahrukh S Rizvi, Alice Gallo De Moraes
Apr 10, 2021·Journal of Inflammation Research·Chunmei XieLokesh Sharma
Mar 24, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexandre FavàOriol Bestard
Feb 27, 2021·The Journal of Clinical Investigation·Rose-Marie RébillardCatherine Larochelle
Apr 14, 2021·Critical Care : the Official Journal of the Critical Care Forum·Fabienne VenetUNKNOWN RICO study group
Mar 5, 2021·European Journal of Clinical Investigation·Alessandro ProttiPietro Caironi
Apr 20, 2021·The Lancet. Respiratory Medicine·Oliver J McElvaneyNoel G McElvaney
May 1, 2021·International Journal of Molecular Sciences·Ghaydaa A ShehataHatem A Elshabrawy
May 10, 2021·The Lancet. Respiratory Medicine·Marcin F OsuchowskiIgnacio Rubio
May 12, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·David S Y OngUNKNOWN European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Respiratory Viruses (ESGREV)
May 18, 2021·Frontiers in Immunology·José Alberto Choreño-ParraJoaquín Zúñiga

❮ Previous
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Methods Mentioned

BETA
flow cytometry
bronchoalveolar lavage
PCR

Clinical Trials Mentioned

NCT04324996
NCT04356508
NCT04379076

Software Mentioned

FlowJo
SPSS Statistics
ELISpot
GraphPad Prism

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