Severe ischemic colitis following olanzapine use - A case report

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
Samuel R FernandesJosé Velosa

Abstract

Ischemic colitis is the most common subtype of intestinal ischemia usually resulting from vasospasm, vessel occlusion or mesenteric hypoperfusion. Neuroleptics have seldom been linked to ischemic colitis by blocking peripheral anticholinergic and antiserotonergic receptors inducing severe gastrointestinal paresis. We report a young patient with severe ischemic colitis requiring surgery due to necrosis of the bowel. After exclusion of other potential causes, olanzapine was admitted as the cause of ischemia. Clinicians should be aware of how to recognize and treat the potentially life-threatening effects of neuroleptics.

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Citations

Nov 24, 2018·Alimentary Pharmacology & Therapeutics·Ziga VodusekLawrence J Brandt
Nov 1, 2016·Current Opinion in Gastroenterology·Ayah Oglat, Eamonn M M Quigley
Apr 30, 2019·American Journal of Therapeutics·Antonella MameliDoris Barcellona
Jul 12, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·María Pilar Guillén-ParedesGraciela Valero Navarro
Dec 27, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Helena RibeiroAntónio Banhudo
Oct 5, 2021·The Journal of International Medical Research·Guangcai YuXiangdong Jian

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