Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Christian M LangeChristoph Sarrazin

Abstract

Entecavir is a potent nucleoside inhibitor of the hepatitis B virus (HBV) polymerase with a high antiviral efficacy and a high genetic barrier to viral resistance. After approval in 2006, knowledge on the side effect profile in patients with advanced liver disease and impaired liver function is still limited. Here, we report on 16 patients with liver cirrhosis and chronic hepatitis B who were treated with entecavir. Five of these patients developed lactic acidosis during entecavir treatment. All patients who developed lactic acidosis had highly impaired liver function (Model for End-Stage Liver Disease [MELD] score >or= 20). Lactic acidosis (lactate 26-200 mg/dL, pH 7.02-7.40, base excess -5 mmol/L to -18 mmol/L) occurred between 4 and 240 days after treatment initiation with entecavir. Lactic acidosis was lethal in one patient but resolved in the other cases after termination/interruption of entecavir treatment. No increased lactate serum concentrations were observed during treatment with entecavir in the other 11 patients with chronic hepatitis B and liver cirrhosis who all had MELD scores below 18. The MELD score correlated with the development of lactic acidosis (P < 0.005) as well as its single parameters bilirubin, intern...Continue Reading

References

Jul 1, 1997·Antimicrobial Agents and Chemotherapy·S F InnaimoR J Colonno
Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gian Luigi AdaniPierluigi Viale
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Mar 10, 2006·The New England Journal of Medicine·Ting-Tsung ChangUNKNOWN BEHoLD AI463022 Study Group
Mar 10, 2006·The New England Journal of Medicine·Ching-Lung LaiUNKNOWN BEHoLD AI463027 Study Group
Aug 26, 2006·Nature Clinical Practice. Nephrology·Vishal Patel, S Susan Hedayati
Dec 7, 2007·Antimicrobial Agents and Chemotherapy·Charles E MazzuccoDaniel J Tenney
Dec 21, 2007·The New England Journal of Medicine·Ching-Lung LaiUNKNOWN Globe Study Group
Jan 12, 2008·Pediatric Transplantation·Umut Selda BayrakciMehmet Haberal
Aug 30, 2008·The American Journal of Gastroenterology·Eugene SchiffRicardo Tamez
Oct 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeHillel Tobias
Dec 5, 2008·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Apr 1, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jung Im SeokDae-Seong Kim
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J Fontana
May 23, 2009·Journal of Clinical Gastroenterology·Stanley Martin CohenJoseph Ahn

❮ Previous
Next ❯

Citations

Jun 21, 2011·Hepatology International·Wai-Kay SetoChing-Lung Lai
Oct 25, 2011·Hepatology International·Geoffrey W McCaughan
Jun 1, 2012·Hepatology International·Yun-Fan LiawMasao Omata
Mar 23, 2011·Nature Reviews. Gastroenterology & Hepatology·Hellan Kwon, Anna S Lok
Oct 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Debika Bhattacharya, Chloe L Thio
Aug 21, 2012·Current Opinion in Infectious Diseases·Vincent Wai-Sun Wong, Joseph Jao-Yiu Sung
Nov 22, 2011·Journal of Gastroenterology and Hepatology·Wai-Kay SetoMan-Fung Yuen
Jun 15, 2012·Journal of Gastroenterology and Hepatology·Cheng WangJinlin Hou
Jun 23, 2011·Infection and Drug Resistance·Melissa Osborn
Nov 19, 2010·World Journal of Gastroenterology : WJG·Sylvia BrostChristoph Eisenbach
Jan 11, 2014·World Journal of Gastroenterology : WJG·Evangelos Cholongitas, George V Papatheodoridis
Jul 12, 2012·Hepatitis Monthly·Mario Rizzetto
May 26, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mohammed Y HasosahKevan Jacobson
Aug 26, 2014·Infectious Disease Clinics of North America·Lindsay A PettyDonald M Jensen
Dec 2, 2011·Current Hepatitis Reports·Yuk-Fai LamChing-Lung Lai
Sep 29, 2015·Expert Review of Anti-infective Therapy·Resat OzarasBurak Isal
Mar 6, 2013·Expert Review of Anti-infective Therapy·Sara A HealyAnn J Melvin
Nov 6, 2015·International Journal of Molecular Sciences·Sha LiYibin Feng
Dec 15, 2012·Expert Review of Gastroenterology & Hepatology·Jörg Petersen, Maria Buti
May 3, 2014·Expert Review of Gastroenterology & Hepatology·Angeline Oi-Shan Lo, Grace Lai-Hung Wong
Jun 10, 2011·Expert Review of Gastroenterology & Hepatology·Irene N Rapti, Stephanos J Hadziyannis
Apr 6, 2013·Expert Opinion on Pharmacotherapy·Matthew D SadlerSamuel S Lee
Nov 13, 2015·Expert Opinion on Pharmacotherapy·Yi-Cheng Chen, Yun-Fan Liaw
Dec 27, 2011·Expert Opinion on Emerging Drugs·Natravis Cox, Hans Tillmann
Jan 12, 2016·Expert Opinion on Drug Safety·Lung-Yi MakMan-Fung Yuen
Jan 6, 2011·Expert Opinion on Biological Therapy·Mauro Viganò, Pietro Lampertico
Jan 12, 2012·Expert Opinion on Drug Safety·Michael P MannsSuchat Wongcharatrawee
Mar 16, 2012·Expert Opinion on Drug Safety·Ezequiel Ridruejo, Marcelo O Silva
Jul 29, 2010·Expert Opinion on Drug Safety·David Yiu-Kuen ButChing-Lung Lai
Nov 26, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Oct 14, 2011·International Journal of Hepatology·Richard Guan, Hock Foong Lui
Dec 15, 2015·Journal of Hepatology·Martin-Walter WelkerChristoph Sarrazin
Jan 29, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Maiko TauraNorito Katoh
Aug 3, 2013·Clinics in Liver Disease·Bruno Roche, Didier Samuel
May 11, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suna YapaliAnna S Lok
Dec 26, 2015·International Journal of Molecular Sciences·Wei-Lun TsaiJin-Shiung Cheng
Apr 28, 2012·Gastroenterology·Steven J Scaglione, Anna S F Lok

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Yun-Fan LiawE R Schiff
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Yun-Fan LiawElizabeth Cooney
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Patrick MarcellinFranck Rousseau
© 2022 Meta ULC. All rights reserved