Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Douglas A DrevetsPieter J M Leenen

Abstract

Monocytes perform diverse roles during infection with the facultative intracellular bacterium Listeria monocytogenes. They are essential as bactericidal cells in host defense but can also become Trojan horses transporting bacteria into the brain. To explain these contrasting roles, we characterized bone marrow (BM) monocytes in steady state and generated during lethal and sublethal L. monocytogenes infection. Ly-6C(high)CD11b(+) BM monocytes expressed high amounts of M-CSFR/CD115 in steady state and 72 h following sublethal infection. However, infection with increasing numbers of bacteria resulted in progressive loss of CD115 and strongly decreased CD115-encoding c-fms mRNA expression. Conversely, analysis of regulatory molecules showed de novo expression of the nonsignaling IL-1RII, CD121b, under the same conditions. Ly-6C(high)CD11b(+) monocytes in circulation also acquired a CD115(neg/low)CD121b(high) phenotype during lethal infection. These BM monocytes showed upregulation of suppressor of cytokine signaling 1 and 3 and IL-1R-"associated kinase-M to a greater extent and/or earlier compared with cells from sublethal infection and showed decreased LPS-induced IL-6 production despite similar levels of surface TLR4 expression. ...Continue Reading

References

Aug 1, 1997·Immunological Reviews·S D Fleming, P A Campbell
Dec 30, 1999·Journal of Leukocyte Biology·S D FlemingP A Campbell
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D StoiberT Decker
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E RovidaP Dello Sbarba
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vera M IrikuraDavid Hirsh
Aug 2, 2002·Cell·Koichi KobayashiRichard A Flavell
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian T Edelson, Emil R Unanue
Oct 24, 2002·Blood·Annette Kolb-MäurerWerner Goebel
Dec 20, 2002·Nature·Carl Nathan
May 2, 2003·Nature Medicine·Niels C RiedemannPeter A Ward
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jesse T MyersJoel A Swanson
Dec 9, 2003·The Journal of Biological Chemistry·Kuniko NakayamaYasuo Ota
Mar 23, 2004·Annual Review of Immunology·Warren S Alexander, Douglas J Hilton
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cord SunderkötterPieter J M Leenen
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas A DrevetsPieter J M Leenen
Apr 16, 2004·Clinical Microbiology Reviews·Douglas A DrevetsRonald A Greenfield
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·Carlos del FresnoEduardo López-Collazo
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stewart J Levine
Jun 2, 2005·Nature Reviews. Immunology·Foo Y LiewLuke A J O'Neill
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan ZimmermannAlexander H Dalpke
Jan 24, 2006·Clinical and Vaccine Immunology : CVI·Michael HeesenTom van der Poll
Aug 19, 2006·The Journal of Clinical Investigation·Jane C DengTheodore J Standiford
Nov 30, 2006·Current Opinion in Hematology·Samuel Wormald, Douglas J Hilton

❮ Previous
Next ❯

Citations

Jan 10, 2013·PloS One·Christina GrothusenBernhard Schieffer
Sep 9, 2015·Frontiers in Immunology·Loems Ziegler-Heitbrock
Feb 19, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grant S Jones, Sarah E F D'Orazio
Dec 17, 2017·Immunological Reviews·Martina MolgoraCecilia Garlanda
Dec 15, 2017·PLoS Pathogens·Felipe H Santiago-Tirado, Tamara L Doering
Aug 1, 2018·Stem Cells·Kristina ProbstBent Brachvogel
Jul 6, 2011·Immunology and Cell Biology·Jason C LenzoJohn A Hamilton
Apr 8, 2015·Current Protocols in Immunology·Douglas A DrevetsPriscilla A Campbell
Jul 14, 2017·Molecular Immunology·Shanshan HuHeinrich Korner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
E A HavellP B Sehgal
The Journal of Immunology : Official Journal of the American Association of Immunologists
Douglas A DrevetsPieter J M Leenen
The Journal of Immunology : Official Journal of the American Association of Immunologists
E A Havell
© 2021 Meta ULC. All rights reserved