PMID: 9446848Mar 7, 1998Paper

Severe malnutrition alters lipid composition and fatty acid profile of small intestine in newborn piglets

The Journal of Nutrition
J M López-PedrosaA Gil

Abstract

The goal of this study was to evaluate the influence of severe protein-energy malnutrition (PEM) on lipid composition and fatty acid profile in the small intestinal mucosa of lactating pigs. Malnutrition was achieved by 80% protein-energy restriction for 30 d (20% of the food intake in the control group) in 7-d-old newborn piglets. Malnourished piglets had significantly lower concentrations of cholesterol, phospholipid and triglycerides in the jejunum and ileum compared with freely fed controls. Fatty acid composition of the intestinal mucosa was severely affected by malnutrition. A sharp decline in the relative percentages of (n-3) and (n-6) long-chain polyunsaturated fatty acids (LC-PUFA) in malnourished piglets paralleled higher (n-9) fatty acid proportions in the total mucosa, microsomes and phospholipids of the jejunum. The structure of the small intestine was severely affected as assessed by light and electron microscopy, and alkaline phosphatase and disaccharidase activities in the intestinal mucosa were also significantly impaired. Plasma from malnourished piglets had significantly lower concentrations of (n-3) and (n-6) LC-PUFA than that of control piglets; however, the fatty acid composition of red blood cell membrane...Continue Reading

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Citations

Jul 9, 2004·The Journal of Veterinary Medical Science·Apichai MekbungwanKoh-En Yamauchi
Mar 30, 2007·Digestive Diseases and Sciences·Natalia NietoAngel Gil
Dec 5, 2019·Animals : an Open Access Journal From MDPI·Silvia Clotilde ModinaAlessia Di Giancamillo
Aug 15, 2000·Annual Review of Nutrition·R P Ferraris, H V Carey
May 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Suzanna AttiaRobert H J Bandsma
May 14, 2003·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·E AlmansaM Díaz
Mar 1, 2008·Animal : an International Journal of Animal Bioscience·A MekbungwanT Buwjoom
Aug 29, 2018·Journal of Animal Physiology and Animal Nutrition·Reza MahdaviGleb Yurievich Kosovsky
Jun 30, 2019·International Journal of Molecular Sciences·John Mackay SøftelandMihai Oltean
Nov 5, 2005·British Poultry Science·B Maneewan, K Yamauchi
Sep 18, 2012·Advances in Nutrition·Sheila K Jacobi, Jack Odle
May 25, 2012·The Journal of Nutrition·Sheila K JacobiJack Odle
Feb 18, 2011·Canadian Journal of Microbiology·Geeta Shukla, Ramandeep Kaur Sidhu
Nov 4, 2016·The Journal of Nutrition·Valeria Di GiovanniRobert Hj Bandsma
Jan 16, 2007·The British Journal of Nutrition·Lucile MontagneBernard Sève
Feb 16, 2021·The British Journal of Nutrition·R M Pinho, E A Maga
Apr 9, 2021·Scientific Reports·Mohamed Karim MaghrabyRobert H J Bandsma
Aug 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ella N SmitE Rudy Boersma

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