Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring

Thyroid : Official Journal of the American Thyroid Association
Susan DowningRosalind S Brown

Abstract

Concern about potential harmful effects of early maternal hypothyroidism (MH) on fetal brain development has led to calls for universal screening early in, or even before, pregnancy. However, evidence in humans that adverse effects are irreversible if thyroid hormone replacement is initiated after the first trimester is limited. Severe MH due to thyrotropin (TSH) receptor blocking antibodies (Abs) is associated with profound cognitive delay in the offspring if MH is untreated or inadequately treated; here, we sought to determine the outcome if treatment is given in early pregnancy. We identified three women who had TSH receptor blocking Ab-induced MH during pregnancy and were treated with L-thyroxine (L-T4), starting at 27 weeks, 5 weeks, and the first month of gestation. The corresponding pretreatment serum TSH levels in the two women in whom data were available were 68 and 65 mU/L, falling to 6 mU/L at 25 and 24 weeks of gestation, respectively. The third woman with MH required 0.5 mg of L-T4 to normalize her thyroid hormone levels by 4 months of gestation. Their infants were also treated with L-T4 after neonatal screening that identified congenital hypothyroidism (CH). Neuropsychological tests to assess intelligence, languag...Continue Reading

References

Jul 1, 1991·Clinical Endocrinology·R Z KleinM L Mitchell
Dec 29, 1994·The New England Journal of Medicine·X Y CaoG R DeLong
Nov 1, 1996·American Journal of Reproductive Immunology : AJRI·A MalekH Schneider
Aug 19, 1999·The New England Journal of Medicine·J E HaddowR Z Klein
Apr 3, 2003·The Journal of Clinical Investigation·Rosalía Lavado-AutricGabriella Morreale de Escobar
Aug 16, 2003·Clinical Endocrinology·Mark D Kilby
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Gabriella Morreale de EscobarFrancisco Escobar del Rey
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Monique H A KesterGabriella Morreale de Escobar
Nov 24, 2004·European Journal of Endocrinology·Gabriella Morreale de EscobarFrancisco Escobar del Rey
Jan 9, 2007·The Journal of Clinical Endocrinology and Metabolism·Gregory A Brent
Feb 10, 2012·The New England Journal of Medicine·John H LazarusNicholas J Wald
Nov 1, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·H Jack BaskinJohn B Tourtelot

❮ Previous
Next ❯

Citations

Mar 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasUNKNOWN American Thyroid Association Spring 2013 Program Committee
Oct 1, 2014·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasUNKNOWN American Thyroid Association Task Force on Thyroid Hormone Replacement
Sep 13, 2013·Journal of Women's Health·T P FoleyE W Naylor
Nov 21, 2015·Thyroid : Official Journal of the American Thyroid Association·Mariacarla MoletiFrancesco Vermiglio
Oct 7, 2015·Thyroid : Official Journal of the American Thyroid Association·Fanni PäkkiläEila Suvanto
Sep 17, 2013·Annals of Neurology·Jonathan D Picker, Christopher A Walsh
Feb 11, 2015·Environmental Geochemistry and Health·John H Lazarus
Jan 7, 2017·Thyroid : Official Journal of the American Thyroid Association·Erik K AlexanderScott Sullivan
Feb 6, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·George J KahalyPaul D Olivo
Jul 6, 2019·Biologie aujourd'hui·Sylvie Remaud, Barbara Demeneix
Nov 5, 2019·Frontiers in Neurology·Daniela TalhadaKarsten Ruscher
Jan 3, 2020·NeoReviews·Liane Eng, Leslie Lam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved