Severe motor-dominant neuropathy with IgM M-protein binding to the NeuAcalpha2-3Galbeta- moiety

Journal of the Neurological Sciences
T OgaT Takai

Abstract

We report the occurrence of a relapsing, severe predominantly motor neuropathy in a 75-year-old man with an IGM-K M-protein binding to gangliosides GM2, GM3, GM4, GD1a, GT1b and LM1. Motor nerve conduction velocities were slowed with conduction block. A superficial peroneal nerve biopsy specimen revealed segmental demyelination and remyelination. The patient improved after repeated plasma exchanges, and the antibody titer decreased in association with clinical recovery. This IgM M-protein has a unique, previously unreported binding specificity for terminal NeuAcalpha2-3Galbeta- moiety in common to all gangliosides bound by the antibody except GM2. M-proteins with this affinity may be involved in the pathogenesis of this and other cases of motor-dominant demyelinating neuropathy.

References

Sep 1, 1989·Journal of Neurology·E BollensenA J Steck
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A A IlyasR O Brady
Nov 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·H J WillisonS C Barnett
Apr 1, 1996·Annals of Neurology·M CarpoG Scarlato

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Citations

Mar 11, 1999·Annals of Neurology·S KusunokiI Kanazawa
Apr 6, 2001·Journal of Clinical Laboratory Analysis·A AlaediniN Latov
Aug 8, 2001·Journal of the Neurological Sciences·K MizutaniH Shibasaki
Apr 4, 2007·Muscle & Nerve·Francesca NotturnoAntonino Uncini

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