Severe neurodevelopmental disability and healthcare needs among survivors of medical and surgical necrotizing enterocolitis: A prospective cohort study

Journal of Pediatric Surgery
Brenna S FullertonTom Jaksic

Abstract

This study characterizes neurodevelopmental outcomes and healthcare needs of extremely low birth weight (ELBW) survivors of necrotizing enterocolitis (NEC) compared to ELBW infants without NEC. Data were collected prospectively on neonates born 22-27weeks' gestation or 401-1000g at 47 Vermont Oxford Network member centers from 1999 to 2012. Detailed neurodevelopmental evaluations were conducted at 18-24months corrected age. Information regarding rehospitalizations, postdischarge surgeries, and feeding was also collected. "Severe neurodevelopmental disability" was defined as: bilateral blindness, hearing impairment requiring amplification, inability to walk 10 steps with support, cerebral palsy, and/or Bayley Mental or Psychomotor Developmental Index <70. Diagnosis of NEC required both clinical and radiographic findings. There were 9063 children without NEC, 417 with medical NEC, and 449 with surgical NEC evaluated. Significantly higher rates of morbidity were observed among infants with a history of NEC. Those with surgical NEC were more frequently affected across all outcome measures at 18-24months corrected age: 38% demonstrated severe neurodevelopmental disability, nearly half underwent postdischarge operations, and a quarte...Continue Reading

Associated Clinical Trials

Citations

Jul 12, 2018·Annals of Surgery·Ruchi AminMarjorie J Arca
Oct 3, 2019·Pediatrics in Review·Fiona WertheimerVictoria Niklas
Mar 14, 2019·Current Pediatric Reviews·Catalina Bazacliu, Josef Neu
Dec 6, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Andreea MateiAugusto Zani
Feb 23, 2021·Frontiers in Pediatrics·Kristine HolgersenPer Torp Sangild
Jun 3, 2021·Pediatrics in Review·Jillian ConnorsDeborah Campbell
Jun 7, 2021·Journal of Pediatric Surgery·George S BethellUNKNOWN BAPS-CASS NEC Investigator Group on behalf of BAPS-CASS
Aug 4, 2021·American Journal of Perinatology·Jennifer B FundoraPamela Donohue

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