Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment

Sleep & Breathing = Schlaf & Atmung
Yasuko ImaiAkira Yamashina

Abstract

Severe obstructive sleep apnea (OSA) directly impairs left ventricular (LV) diastolic function. Left atrial volume index (LAVI), an independent predictor of future cardiovascular events, is also related to OSA severity. This study aimed to assess whether OSA is associated with an increase in LAVI independently of LV diastolic function. Two hundred six OSA patients (apnea hypopnea index, AHI ≥ 5/h) without cardiac disease, hypertension, and diabetes were enrolled. They underwent overnight fully attended polysomnography and 2-dimensional echocardiography in order to estimate LA volumes and LV diastolic function which was assessed by the ratio of transmitral early diastolic flow velocity to late diastolic flow velocity (E/A), deceleration time, and mitral annular velocity (e') which was derived from tissue Doppler imaging. Patients were divided into two groups based on AHI, namely, group M (5 ≤ AHI < 30/h) and group S (AHI ≥ 30/h). The LAVI value in group S was significantly larger than that in group M (20 ± 5 vs. 23 ± 5 mL/m(2), P < 0.001). E/A in group S was significantly lower than that in group M (P < 0.001), whereas the ratio of E to e' (E/e') in group S was significantly higher than that in group M (P < 0.001). AHI showed a ...Continue Reading

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Citations

Aug 25, 2017·Journal of Sleep Research·Henrik Holtstrand HjälmErik Thunström
Mar 24, 2018·Journal of Hypertension·Paola MattalianoGianfranco Parati
Dec 26, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Radu SascăuFlorin Mitu
Jan 8, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Mohammad A KhanDipan J Shah
Aug 18, 2020·Journal of Human Hypertension·Cesare CuspidiGuido Grassi

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