Severe obstructive sleep apnea: sleepy versus nonsleepy patients

The Laryngoscope
Arie OksenbergDonald S Silverberg

Abstract

To compare demographic and polysomnographic data of sleepy versus nonsleepy severe obstructive sleep apnea (OSA) patients according to the Epworth Sleepiness Scale (ESS). Retrospective cohort. Six hundred forty-four consecutive severe (apnea-hypopnea index [AHI] >or= 30) adult OSA patients who underwent a polysomnographic evaluation in our sleep disorders unit. ESS data were available in 569 (88.3%). Three hundred twenty-seven (57.5%) patients had ESS > 10. Sleepy severe OSA patients are slightly younger and more obese than nonsleepy patients. These sleepy patients have shorter sleep latency and lower percentage of slow wave sleep. They consistently show a higher AHI, both supine and lateral AHI, have a higher number of short arousals, and a higher arousal index. They also have higher snoring loudness in the supine and both lateral positions and a lower minimal SaO(2) in rapid eye movement and non-rapid eye movement sleep. After adjusting for confounders, a logistic regression model points to apnea index as a significant prognostic factor for excessive daytime sleepiness. Severe OSA sleepy patients have a syndrome that is significantly more severe than nonsleepy patients. Sleepy patients have worse sleep-related breathing param...Continue Reading

References

Jul 1, 1988·Chest·C GuilleminaultG Nino-Murcia
Oct 1, 1968·Journal of Projective Techniques & Personality Assessment·D B Pryor
Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·N M PunjabiK Bandeen-Roche
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·D J GottliebM W Mahowald
Jun 30, 2004·Sleep Medicine·Udaya Seneviratne, Kathiravelu Puvanendran
Sep 21, 2005·Sleep·Vishesh K KapurF Javier Nieto
Mar 14, 2007·Atherosclerosis·Michael SaletuJosef Zeitlhofer
Mar 16, 2007·The European Respiratory Journal·O MedianoF Barbé
Sep 8, 2007·American Journal of Respiratory and Critical Care Medicine·Charles F P George
Mar 4, 2008·The European Respiratory Journal·A BaHammam
May 17, 2008·Sleep Medicine·Nuria RoureFerran Barbé
Aug 2, 2008·The European Respiratory Journal·P CastiglioniG Parati
Jun 10, 2009·Archives of Internal Medicine·Kristen L KnutsonDiane S Lauderdale

❮ Previous
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Citations

Jan 24, 2013·Sleep & Breathing = Schlaf & Atmung·Jorge Rey de Castro, Edmundo Rosales-Mayor
Mar 19, 2014·Journal of Psychosomatic Research·Daniel NeuOlivier Le Bon
Dec 3, 2014·Critical Care Nursing Quarterly·Penelope Z Strauss
Jan 4, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ravi GuptaGirish Sindhwani
Jul 16, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Reginald Goodday, Susan Bourque
Aug 26, 2010·The Medical Clinics of North America·Seckin O Ulualp
Oct 9, 2012·European Journal of Internal Medicine·Aibek E Mirrakhimov, Erkin M Mirrakhimov
Jun 14, 2016·Annals of Indian Academy of Neurology·Sapna Erat SreedharanAshalatha Radhakrishnan
Jan 25, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Mikiko OhashiKeiichi Fukuda
Sep 7, 2018·Breathe·Kostas ArchontogeorgisPaschalis Steiropoulos
Dec 25, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Nejat Altintas, Renata L Riha
Jun 13, 2020·Sleep & Breathing = Schlaf & Atmung·Xingjian WangWei Wang
Oct 24, 2019·Sleep Medicine Clinics·Maria R BonsignoreFrancesco Fanfulla
Oct 4, 2020·The European Respiratory Journal·Maria R BonsignoreWalter T McNicholas
May 11, 2020·Sleep Medicine Clinics·Renee MondererMichael Thorpy
Mar 12, 2021·Sleep·Atul MalhotraDaniel J Gottlieb
Apr 23, 2021·Respiratory Research·Nicole PizzorniPierachille Santus
Jun 4, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I A FilchenkoYu V Sviryaev
Jul 31, 2021·Journal of Sleep Research·Arie OksenbergTimo Leppänen
Aug 27, 2021·Sleep & Breathing = Schlaf & Atmung·David Landzberg, Kanika Bagai

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