PMID: 11575020Sep 29, 2001

Severe oral manifestations of chronic graft-vs.-host disease

The Journal of the American Dental Association
C M FrançaN Soares de Araújo

Abstract

Graft-vs.-host-disease, or GVHD, is the main cause of morbidity in patients who have received bone marrow transplants. Chronic GVHD, or cGVHD, occurs 100 days or more after the transplant procedure and may take the form of various oral manifestations. A 23-year-old woman received an allogeneic bone marrow transplant. Although prophylactic therapy was provided, the patient developed cGVHD. Appropriate therapy was initiated, and it received a good clinical response at all sites affected by cGVHD, except in the oral cavity. The patient received complete symptomatic relief through revised systemic therapy, improved oral hygiene, use of topical medications and a monitored diet. Effective intervention by dentists is an important part of increasing treatment effectiveness and improving quality of life in patients who received bone marrow transplants.

References

Jan 1, 1992·British Journal of Haematology·M StockschlaederK M Sullivan
Aug 1, 1984·Archives of Internal Medicine·Mark M SchubertR Storb
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Citations

Sep 23, 2010·Clinical Oral Investigations·Johannes K-H MeierInternational Consensus Conference on Clinical Practice in cGVHD
Dec 25, 2007·Dental Clinics of North America·Mark M Schubert, M E P Corrêa
Apr 27, 2012·British Journal of Haematology·Fiona L DignanBritish Society for Blood and Marrow Transplantation
Jan 14, 2017·Expert Opinion on Pharmacotherapy·Yehuda ZadikMichael Y Shapira
Jul 1, 2020·International Dental Journal·Sharon EladYehuda Zadik

Related Concepts

Mycophenolate mofetil hydrochloride
Hypoplastic Anemia
Anti-Inflammatory Agents
Cellestoderm
Glucocorticoid Effect
Graft-vs-Host Disease
Immunosuppressive Agents
IMP Dehydrogenase
Methotrexate, (DL)-Isomer
Mouth Diseases

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