Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Karis Kin-Fong ChengDavid R Thompson

Abstract

This study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC...Continue Reading

References

Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D OsobaJ Pater
Jan 29, 2000·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L A BellmH J Fuchs
Aug 17, 2002·Oncology Nursing Forum·Sally BorbasiDan Evans
May 14, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andy TrottiMarya D Zilberberg
Oct 22, 2003·Journal of Clinical Epidemiology·Jean Mundahl Engels, Paula Diehr
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kim RobienCornelia M Ulrich
Dec 17, 2004·The New England Journal of Medicine·Ricardo SpielbergerChristos Emmanouilides
May 17, 2006·Oral Diseases·C ScullyP D Diz
Aug 10, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Pamela HorsleyJohn Bashford
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee S RosenStephen Clarke
Feb 23, 2007·Journal of Clinical Nursing·Karis Kin-Fong Cheng
Apr 18, 2007·Bone Marrow Transplantation·K O AndersonC S Cleeland
Aug 19, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Dorothy M KeefeRachel J Gibson
Feb 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole BlijlevensUNKNOWN European Blood and Marrow Transplantation Mucositis Advisory Group
May 27, 2008·International Journal of Radiation Oncology, Biology, Physics·David I RosenthalCharles S Cleeland
Aug 5, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Karis K F ChengDavid R Thompson

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Citations

Aug 21, 2012·World Journal of Clinical Oncology·Simon N RogersNaseem Ghazali
Jan 31, 2014·Photomedicine and Laser Surgery·Ana Carolina Carneiro FreitasAlyne Simões
Feb 21, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M GobboM Biasotto
Sep 17, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Harriët Jager-WittenaarJan L N Roodenburg
Oct 4, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Paul UrbainHans-Konrad Biesalski
Dec 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Karis Kin Fong ChengJoel B Epstein
Dec 12, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ajay Prashad GautamShantling Nigudgi
Feb 7, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rebecca L Mercieca-BebberFabio Efficace
Aug 14, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ajay Prashad GautamBejadi M Vadhiraja
Oct 28, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andreza BarkokebasJair Carneiro Leão
Feb 24, 2015·Journal of Photochemistry and Photobiology. B, Biology·Ajay Prashad GautamVausudev Guddattu
Jul 6, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Melike Demir DoğanRasim Meral
Feb 2, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jeevendra KanagalingamHanlim Moon
May 8, 2018·Oncology Research and Treatment·Karin BergerHelmut Ostermann
Jun 22, 2011·Nursing Research·Karis K F ChengDavid R Thompson
Nov 22, 2018·International Journal of Nursing Practice·Seher Çakmak, Nesrin Nural
Jan 5, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Marilia Oliveira MoraisElismauro Francisco Mendonça
May 23, 2014·Journal of Investigative and Clinical Dentistry·Eleni A Georgakopoulou, Crispian Scully
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Douglas E PetersonStephen T Sonis
Sep 10, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Gary DengJun J Mao
Sep 17, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Fahimeh PakravanPegah Noorshargh
Mar 19, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Hironobu HataYoshimasa Kitagawa
Dec 24, 2019·International Journal of Clinical Pediatric Dentistry·Isabella LA RibeiroAna Mg Valença
Jul 3, 2021·Journal of Clinical Medicine·Wakako YatsuokaYasuhito Uezono
Oct 16, 2021·BMJ Supportive & Palliative Care·Kenro HirataTakanori Kanai
Jul 28, 2018·Journal of Pain and Symptom Management·Bianca Sakamoto Ribeiro PaivaCarlos Eduardo Paiva

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