Severe outcomes associated with respiratory viruses in newborns and infants: a prospective viral surveillance study in Jordan

BMJ Open
Najwa Khuri-BulosNatasha Halasa

Abstract

To assess virus-specific hospitalisation rates, risk factors for illness severity and seasonal trends in children hospitalised with acute respiratory infections (ARI). Prospective cohort study. A government hospital serving low-income and middle-income population in Amman, Jordan. Children under 2 years of age hospitalised with fever and/or respiratory symptoms (n=3168) from 16 March 2010 to 31 March 2013. Children with chemotherapy-associated neutropenia and newborns who had never been discharged after birth were excluded from the study. Hospitalisation rates and markers of illness severity: admission to intensive care unit (ICU), mechanical ventilation (MV), oxygen therapy, length of stay (LOS) and death. Of the 3168 subjects, 2581 (82%) had at least one respiratory virus detected, with respiratory syncytial virus (RSV) being the most predominant pathogen isolated. During admission, 1013 (32%) received oxygen therapy, 284 (9%) were admitted to ICU, 111 (4%) were placed on MV and 31 (1%) children died. Oxygen therapy was higher in RSV-only subjects compared with human rhinovirus-only (42%vs29%, p<0.001), adenovirus-only (42%vs21%, p<0.001) and human parainfluenza virus-only (42%vs23%, p<0.001) subjects. The presence of an unde...Continue Reading

Citations

Oct 31, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A LimB Paes
Nov 2, 2019·Influenza and Other Respiratory Viruses·Siddhivinayak HirveUNKNOWN WHO RSV surveillance Group
Sep 24, 2020·Journal of Medical Virology·Megan C FreemanNatasha Halasa
Nov 12, 2020·Influenza and Other Respiratory Viruses·Stephanie L RolsmaNatasha B Halasa
Nov 10, 2020·The Pediatric Infectious Disease Journal·Zaid HaddadinNatasha B Halasa
Sep 26, 2020·Expert Review of Anti-infective Therapy·Xavier Carbonell-EstranyBosco Paes
Dec 20, 2020·Journal of the Pediatric Infectious Diseases Society·Olajumoke O FadugbaNatasha B Halasa
Dec 30, 2020·Microorganisms·Sonia BianchiniSusanna Esposito
Mar 29, 2021·The Journal of Pediatrics·Zaid HaddadinNatasha B Halasa
Jul 15, 2021·The Pediatric Infectious Disease Journal·Ahmad YanisNatasha B Halasa

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BETA
PCR

Software Mentioned

REDCap
R

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