Severe pertussis infection: A clinicopathological study

Medicine
Fernando PalvoAna Paula de Carvalho Panzeri Carlotti

Abstract

We aimed to investigate the clinicopathological features of pertussis in children admitted to a tertiary-care university hospital in Brazil.This was a retrospective cohort study of all pediatric hospital admissions with pertussis from January 1, 2008 to December 31, 2014. We also reported the autopsy findings in children who died.Fifty-five patients admitted to the hospital over the study period had laboratorial confirmation of Bordetella pertussis infection, 17 (30.9%) needed pediatric intensive care unit (PICU) admission and 6 (10.9%) died. All patients who died were younger than 60 days old and unvaccinated for pertussis; 50% of them had coinfection with respiratory syncytial virus. Leukocyte count ≥40,000/mm at hospital admission was an independent risk factor for PICU admission. Mean heart rate during hospitalization ≥160 bpm was an independent risk factor for death. A cut-off point of 41,200 leukocytes/mm at hospital admission had sensitivity of 64.7% and specificity of 89.5% to predict PICU admission (area under the curve 0.75) and sensitivity of 100% and specificity of 81.6% to predict death (area under the curve 0.93). Autopsy showed medial thickening of small pulmonary arteries in 80% of patients who had pulmonary hyp...Continue Reading

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Citations

Aug 22, 2018·Infection and Immunity·Lindsey I ZimmermanTod J Merkel
May 23, 2019·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Márcia Borges Machado, Saulo Duarte Passos
Jun 30, 2019·Toxins·Karen ScanlonNicholas Carbonetti
Dec 29, 2020·Clinical Case Reports·Nedaa AldairiYasser Kazzaz
Apr 19, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Florence BirruRaghad Al-Abdwani
May 8, 2021·Annals of Intensive Care·Mathilde Coquaz-GaroudetEtienne Javouhey

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Methods Mentioned

BETA
PCR

Software Mentioned

Antro
SAS

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