Severe pneumococcal pneumonia: new strategies for management

Current Opinion in Critical Care
Christine C C Chiou, Victor L Yu

Abstract

Streptococcus pneumoniae is the leading cause of community-acquired pneumonia worldwide and is the most likely causative pathogen in patients with community-acquired pneumonia admitted to the intensive care unit. Bacteremic pneumococcal pneumonia is an advanced stage of severe pneumococcal pneumonia. Improvement in the management of bacteremic pneumococcal pneumonia has the potential for improving the survival for severe pneumococcal pneumonia. Non-culture methods, especially the Binax urinary antigen test, can increase the diagnostic yield for pneumococcal pneumonia, allowing targeted antimicrobial therapy (specifically penicillin). In-vitro resistance to penicillin has increased over the past decade; however, it has not led to clinical failure when used for pneumococcal pneumonia. Hospitalized patients with community-acquired pneumonia should have blood cultures obtained to confirm the possibility of bacteremic pneumococcal pneumonia. Based on pharmacodynamic properties, parenteral penicillin remains the drug of choice to treat pneumococcal pneumonia regardless of in-vitro resistance. Combination antimicrobial therapy will likely improve survival of patients with bacteremic pneumococcal pneumonia among the subset of criticall...Continue Reading

References

Aug 1, 1992·American Journal of Diseases of Children·I R Friedland, K P Klugman
May 1, 1988·Annals of Internal Medicine·R V SimsJ S Schwartz
Aug 24, 1995·The New England Journal of Medicine·Roman PallaresFrancesc Gudiol
Feb 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jordi CarratalàFrancesc Gudiol
Oct 29, 1997·JAMA : the Journal of the American Medical Association·J E SiskJ C Butler
Dec 24, 1997·Chest·C S BryanM S Stinson
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Jan 19, 1999·JAMA : the Journal of the American Medical Association·G L ArmstrongR W Pinner
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·S EwigJ Mensa
Aug 18, 1999·The American Journal of Medicine·M A Mufson, R J Stanek
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G S TurettE E Telzak
Feb 10, 2000·American Journal of Public Health·D R FeikinJames H Jorgensen
Mar 23, 2000·Respirology : Official Journal of the Asian Pacific Society of Respirology·H WatanabeT Nagatake
Jun 7, 2000·American Journal of Infection Control·E M CastilloC Kelly
Aug 19, 2000·The Journal of Infectious Diseases·Mats KalinM A Woodhead
Mar 10, 2001·The New England Journal of Medicine·G R BernardRecombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Aug 30, 2001·Archives of Internal Medicine·G W WatererRichard Wunderink
Dec 26, 2001·Archives of Internal Medicine·Daniel M MusherG V Doern
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
Jan 17, 2002·The New England Journal of Medicine·E RiversEarly Goal-Directed Therapy Collaborative Group
Feb 13, 2002·The Pediatric Infectious Disease Journal·Sheldon L KaplanWilliam J Barson
Feb 28, 2002·The Journal of Antimicrobial Chemotherapy·William Bishai
Oct 19, 2002·International Journal of Antimicrobial Agents·T M File546, 547, 548, 549, 550, 551, 556, 557 and 592 Clinical Study Groups
Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A MartínezJosep Mensa
Mar 5, 2003·The Journal of Antimicrobial Chemotherapy·D Van KerkhovenJ Verhaegen
May 2, 2003·The New England Journal of Medicine·Cynthia G WhitneyActive Bacterial Core Surveillance of the Emerging Infections Program Network
May 2, 2003·The New England Journal of Medicine·Lisa A JacksonVaccine Safety Datalink
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor L YuInternational Pneumococcal Study Group
May 1, 1964·Annals of Internal Medicine·R AUSTRIAN, J GOLD
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellInfectious Diseases Society of America
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Javier AspaPneumococcal Pneumonia in Spain Study Group
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jae-Hoon SongAsian Network for Surveillance of Resistant Pathogens Study Group
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Larry M BaddourInternational Pneumococcal Study Group
Nov 3, 2004·International Journal of Antimicrobial Agents·Octavian C IoachimescuPaul B Iannini
Nov 24, 2004·Infectious Disease Clinics of North America·Joseph F Plouffe, Daniel R Martin
Dec 22, 2004·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·K WeissJ Tremblay
Mar 23, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E García VázquezA Torres
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Igor A GuchevLeonid S Stratchounski
May 14, 2005·Critical Care Medicine·Pierre-Francois LaterrePROWESS Clinical Evaluation Committee
Oct 11, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S HarbarthD Pittet
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lance R Peterson
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christine C C Chiou
Jan 3, 2006·Seminars in Respiratory and Critical Care Medicine·A OrtqvistMats Kalin

Citations

Oct 16, 2008·Clinical Microbiology Reviews·Damiana ChiavoliniSusanna Ricci
Jan 18, 2014·Journal of Clinical Monitoring and Computing·Jan KarstenDaniel Drömann
Nov 30, 2010·Pediatric Clinics of North America·Lorin R Browne, Marc H Gorelick
Dec 26, 2007·Seminars in Pediatric Surgery·Pramod S Puligandla, Jean-Martin Laberge
Apr 7, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G VernetK P Klugman
Nov 20, 2016·Journal of Clinical Pathology·Angel BoulosPeter Coyle
Apr 21, 2017·The Journal of Experimental Medicine·Justin F DenisetPaul Kubes

Related Concepts

Polychemotherapy
Penicillin
Streptococcal Pneumonia
Bacteremia
Community-Acquired Infections
Macrolides
Antibiotic Resistance, Bacterial

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