PMID: 11332665May 3, 2001Paper

Severe, rapidly progressive human immunodeficiency virus type 1 disease in newborns with coinfections

The Pediatric Infectious Disease Journal
T PillayH M Coovadia

Abstract

To describe a severe form of rapidly progressive HIV-1 infection manifesting in the neonatal period. Prospective cohort study, King Edward VIII Hospital, Durban, South Africa. HIV-1-exposed neonates with hepatosplenomegaly, lymphadenopathy or persistent pneumonia within the first 28 days of life were investigated for perinatal infections. Confirmation of neonatal HIV-1 infection, HIV-1 subtype and clinical outcomes were studied. Twenty-three (72%) of 32 symptomatic HIV-1-exposed neonates recruited at a mean of 15.2 days were HIV-1-infected. HIV-1 infection was detected in 5 patients who were tested within 48 h of birth, confirming congenital infection. Congenital infection was not excluded in any case. Median neonatal viral load at recruitment was 471,932 copies/ml and median CD4 was 777 cells/mm3. The predominant clinical presentation was growth retardation and prematurity. Perinatal infections detected included: tuberculosis (8), syphilis (6) and cytomegalovirus (10). All of the neonates with perinatal tuberculosis were HIV-1-coinfected. Maternal and neonatal viral load and CD4 at recruitment were not statistically different between the groups with tuberculosis vs. other coinfections. Gag gene sequence analysis confirmed clos...Continue Reading

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Citations

Jul 15, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sheryle R RogersonRobin L Broadhead
Mar 5, 2004·The Lancet Infectious Diseases·T PillayH Coovadia
Aug 30, 2007·The Journal of Infectious Diseases·B J MaraisN Beyers
Nov 30, 2006·The Pediatric Infectious Disease Journal·Douglas M BowleyGraeme J Pitcher
Jan 27, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebecca E CookTroy D Moon
Apr 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·T Duke
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Jul 28, 2016·Paediatrics and International Child Health·Khakhu Tshilidzi Mathivha, Sithembiso Velaphi
Sep 14, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elaine J AbramsAndrea J Ruff
Mar 24, 2009·Seminars in Fetal & Neonatal Medicine·M Adhikari

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