Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report

Case Reports in Oncology
Angela DamatoAnnibale Versari

Abstract

Rhabdomyolysis is defined as dissolution of striped muscle characterized by leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. This is an uncommon side effect of trabectedin which is used in second-line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. Here, we describe a case of reversible rhabdomyolysis in a male patient with recurrent metastatic synovial sarcoma of the hand, with marked 18F-FDG uptake into his skeletal muscles, after 4 cycles of trabectedin, and who at the same time was taking an alternative medicine (bioflavonoids) suspected of triggering this adverse event.

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Citations

Jan 25, 2018·British Journal of Clinical Pharmacology·Charles AwortweBernd Rosenkranz
Jan 18, 2021·Journal of Medical Case Reports·Serenella SerinelliDaniel J Zaccarini
Jul 26, 2021·Cancer Chemotherapy and Pharmacology·Audrey BellesoeurAudrey Thomas-Schoemann
Aug 27, 2021·Medicines·Mary Beth BabosPaul Herscu

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