Severe sepsis and septic shock: management and performance improvement

Virulence
Christa A SchorrR P Dellinger

Abstract

Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Septic Shock were first published in 2004, revised in 2008, and recently revised again and published in 2013. The first part of this manuscript is a summary of the 2013 guidelines with some editorial comment. The second part of the manuscript characterizes hospital based sepsis performance improvement programs and highlights the sepsis bundles from the Surviving Sepsis Campaign as a key component of such a program.

References

Apr 1, 1981·Scottish Medical Journal·J J BelchC R Prentice
Apr 1, 1994·Anesthesia and Analgesia·K C MeyerD B Coursin
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
Apr 29, 1998·Critical Care Medicine·P E BollaertA Larcan
Dec 10, 1998·Journal of Internal Medicine·L LeiboviciS D Pitlik
Jan 11, 2000·Critical Care Medicine·R J BealeD J Bihari
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Aug 31, 2000·Critical Care Medicine·D LeDouxE C Rackow
Aug 31, 2000·Critical Care Medicine·C MartinX Thirion
Apr 20, 2001·Intensive Care Medicine·M F JimenezUNKNOWN International Sepsis Forum
Sep 5, 2001·Kidney International·R L MehtaUNKNOWN Collaborative Group for Treatment of ARF in the ICU
Oct 26, 2001·JAMA : the Journal of the American Medical Association·B L WarrenUNKNOWN KyberSept Trial Study Group
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Jan 31, 2002·Intensive Care Medicine·John A KellumWalter T Linde-Zwirble
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Oct 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marcello TonelliDavid Feller-Kopman
Nov 12, 2002·American Journal of Respiratory and Critical Care Medicine·Didier KehHerwig Gerlach
Dec 11, 2002·JAMA : the Journal of the American Medical Association·Howard L CorwinUNKNOWN EPO Critical Care Trials Group
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
May 27, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Juan C MontejoUNKNOWN Spanish Society of Intensive Care Medicine and Coronary Units
Jun 26, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Apr 20, 2004·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Management Guidelines Committee
May 28, 2004·The New England Journal of Medicine·Simon FinferUNKNOWN SAFE Study Investigators
Jul 23, 2004·The New England Journal of Medicine·Roy G BrowerUNKNOWN National Heart, Lung, and Blood Institute ARDS Clinical Trials Network
Jun 24, 2005·Intensive Care Medicine·Marjut VarpulaVille Pettilä
Dec 15, 2005·Critical Care Medicine·Salmaan KanjiPaul C Hebert
Jan 21, 2006·Critical Care Medicine·Christian J WiedermannUNKNOWN KyberSept Investigators

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Citations

Jun 18, 2015·Molecular Medicine Reports·Xiao-Mei LuYan-Qiu Yu
Dec 3, 2015·Surgical Infections·Taku OshimaShigeto Oda
May 12, 2015·The American Journal of Emergency Medicine·Nian-Fang LuDe-Gang Yang
Mar 31, 2015·Critical Care Clinics·Omar Badawi, Erkan Hassan
Jul 9, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shu-Ling FanDaniel G Remick
Mar 12, 2016·Critical Care Medicine·Maoping ChuChunxiang Zhang
May 2, 2014·Life Sciences·Brandi D FreemanMahalia S Desruisseaux
Apr 12, 2017·Critical Care : the Official Journal of the Critical Care Forum·Kristo EriksonTero Ilmari Ala-Kokko
Jan 18, 2018·Surgical Infections·Sara A BuckmanJohn E Mazuski
Feb 17, 2018·Cell & Bioscience·Katharina Rump, Michael Adamzik
Nov 9, 2018·BMC Health Services Research·Anders ErssonJonas Borell
Apr 27, 2018·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Gamal M HasanFahad Al-Sohime
Aug 31, 2020·The Journal of Critical Care Medicine·Emoke AlmasySanda Maria Copotoiu

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