Severe Sepsis in Elderly Patients Undergoing Gastrointestinal Surgery-a Prospective Multicenter Follow-up Study of Finnish Intensive Care Units

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Mika UkkonenFinnsepsis Study Group

Abstract

We aimed to evaluate the outcome of elderly patients with severe sepsis after alimentary tract surgery. A prospective study was conducted in 24 intensive care units (ICU) in Finland. Four thousand five hundred consecutive patients were admitted to ICUs and 470 patients fulfilled the criteria for severe sepsis. All patients who had undergone gastrointestinal surgery were included. The outcomes of elderly (≥65 years) and younger patients were compared. The key factor under analysis was death from any cause during the hospitalization or within 1 year after the surgery. A total of 73 elderly patients (and 81 younger patients) were found to have severe alimentary tract surgery-related sepsis. The mean age of the elderly patients was 76.4 years, and 56.2 % were female. The most common indication for surgery was acute cholecystitis (21.9 %), followed by acute diverticulitis (13.7 %), and gastroduodenal ulcer (13.7 %). The anatomic site of the infection was intra-abdominal in 86.3 % of cases, the second most common being pulmonary (13.7 %). In-hospital mortality was 47.9 % and 1-year mortality 64.4 %. Of the discharged patients, 31.6 % died within 1 year. Patients who died were older and more frequently had concomitant conditions. The ...Continue Reading

References

Jul 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G S CooperR A Salata
Jan 23, 1999·The New England Journal of Medicine·A P Wheeler, G R Bernard
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Nov 1, 2002·The Lancet Infectious Diseases·Gaëtan Gavazzi, Karl-Heinz Krause
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Feb 17, 2005·Age and Ageing·Saulius VosyliusJuozas Ivaskevicius
Feb 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy D GirardE Wesley Ely
Mar 4, 2005·Journal of the American Geriatrics Society·Mary Beth HamelJennifer Daley
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Aug 19, 2006·Critical Care Medicine·Paul E Marik
Nov 23, 2006·Journal of the American College of Surgeons·Florence E TurrentineR Scott Jones
Jul 17, 2007·Clinics in Geriatric Medicine·Timothy D Girard, E Wesley Ely
Oct 20, 2007·Acta Anaesthesiologica Scandinavica·M VarpulaUNKNOWN Finnsepsis Study Group
Feb 27, 2009·Critical Care Medicine·Sari KarlssonUNKNOWN Finnsepsis Study Group
Dec 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinJohn G Bartlett
Apr 22, 2010·Scandinavian Journal of Public Health·M Riita LeskinenRiitta L Antikainen
Jun 24, 2010·Annals of Surgery·Todd R VogelStephen F Lowry
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Theodore J IwashynaKenneth M Langa
Mar 26, 2011·Journal of Intensive Care Medicine·Prashant NasaVikas Arora
Nov 15, 2011·JAMA : the Journal of the American Medical Association·Allan J WalkeyEmelia J Benjamin
Sep 25, 2012·Lancet·Rupert M PearseUNKNOWN European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Nov 26, 2013·World Journal of Surgery·Tapio HakalaHannu Paajanen
Nov 26, 2013·The British Journal of Surgery·D G WeberZ J Balogh
May 20, 2014·JAMA : the Journal of the American Medical Association·Vincent LiuTheodore J Iwashyna

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Citations

Oct 11, 2019·Journal of Gastric Cancer·Ali Guner, Hyoung-Il Kim
Nov 11, 2021·Journal of Intensive Care Medicine·Anne C M CuijpersMarcel C G van de Poll

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