PMID: 8940740Nov 1, 1996Paper

Severe Shwachman-Diamond syndrome and invasive parvovirus B19 infection

Pediatric Hematology and Oncology
R MinieroM Musiani

Abstract

Parvovirus B19 (PVB19) is the causative agent of infectious erythema. In healthy children the virus causes transient erythroid aplasia, whereas in children with chronic hemolytic anemias it can cause severe aplastic crises, and in immunodeficient individuals it can produce chronic red cell aplasia. If contracted during pregnancy, the infection may induce serious damage to the fetus (abortion or hydrops fetalis). Shwachman-Diamond (S-D) syndrome, a rare autosomal recessive condition, consists of exocrine pancreatic insufficiency plus neutropenia; many patients develop either anemia or thrombocytopenia or both. We describe a newborn baby with severe congenital bone marrow failure who was diagnosed with S-D syndrome and persistence of PVB19 virus contracted by the mother in the third trimester of pregnancy.

References

Feb 1, 1992·American Journal of Hematology·J W Harris
Apr 1, 1990·British Journal of Haematology·N J Barrios, D V Kirkpatrick
Jan 22, 1987·The New England Journal of Medicine·A AnandB J Cohen
May 1, 1980·Archives of Disease in Childhood·P J AggettJ T Harries
Dec 1, 1994·British Journal of Haematology·K R HartmanN S Young
Aug 1, 1994·British Journal of Haematology·N FrickhofenJ L Abkowitz

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Citations

Feb 11, 2005·The Pediatric Infectious Disease Journal·Zachary M Grinspan, Cheryl A Pikora
Nov 4, 2016·Clinical Microbiology Reviews·Jianming QiuNeal S Young

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