Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis

The Pediatric Infectious Disease Journal
Rima McLeodToxoplasmosis Study Group

Abstract

A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines. Symptoms resolved when systemic corticosteroids were administered. This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.

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Citations

Mar 2, 2011·Journal of Computer-aided Molecular Design·Sandhya KortagereWilliam J Welsh
Sep 14, 2012·Journal of Medicinal Chemistry·Alina FomovskaRima McLeod
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