Severe thrombotic tendency associated with a type I plasminogen deficiency

American Journal of Hematology
F W LeebeekD W Traas

Abstract

We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, electrophoretic mobility on crossed immunoelectrophoresis, molecular weight, and binding to lysine sepharose. All other hemostatic parameters predisposing to recurrent thrombosis were normal. A stimulation test with desmopressin acetate (DDAVP) showed a normal plasma rise of both tissue plasminogen activator and factor VIIIR:WF. This isolated plasminogen deficiency apparently is due to a decreased synthesis of a normal plasminogen molecule and is associated with a severe thrombotic tendency.

References

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Citations

Sep 14, 2001·Pediatric Annals·I Warrier
Sep 29, 2007·Journal of Thrombosis and Haemostasis : JTH·V SchusterK Tefs
Dec 16, 2016·Scientific Reports·Laura Martin-FernandezJosé Manuel Soria
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Oct 18, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Xiaoli ChengLihong Yang
Nov 8, 2002·Archives of Pathology & Laboratory Medicine·John T Brandt

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