Severe toxic epidermal necrolysis precipitated by amphetamine use

The Australasian Journal of Dermatology
Hugh RobertsDouglas Gin

Abstract

A 48-year-old man presented with a maculopapular truncal rash 9 days following intravenous amphetamine use. He subsequently developed widespread bullae over his trunk and upper limbs. Treatment was initially commenced with intravenous hydrocortisone. A diagnosis of toxic epidermal necrolysis was made and the treatment was changed to intravenous immunoglobulin at a lower dose than requested. At the height of the reaction, there was 90% body surface area involvement with tri-mucosal involvement. His response to the intravenous immunoglobulin was poor and was complicated by infection with methicillin-resistant Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa. Gradual re-epithelialization took place over the next 6 weeks.

References

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Citations

Oct 21, 2006·Journal of the American Academy of Dermatology·Warren R Heymann
Oct 5, 2010·Journal of Lower Genital Tract Disease·Darion M RowanHiromel de Silva

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